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1
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Development and validation of an ultra-fast liquid chromatographic method for the quality control of famotidine formulations using a short monolithic stationary phase

100%
Tzanavaras P.
Open Chemistry
|
2011
|
vol. 9
|
issue 3
446-452
EN
An HPLC method for the quality control of famotidine (FMT) containing formulations has been developed and validated. The combination of a short monolithic column (Chromolith® RP-18e 50 × 4.6 mm i.d.) and an elevated flow rate (3.0 mL min−1) enabled the proposal of a high-throughput analytical scheme capable of reliable operation in a demanding industrial environment. Detection was carried out at 265 nm. Thorough validation of the method included linearity (5–150%), limits of detection (0.13%) and quantification (0.41%), selectivity, precision (within- and day-to-day), accuracy and ruggedness. The new method was applied successfully to the analysis of samples (assay, dissolution, dosage & blending uniformity) during the production of four validation batches of FMT-containing tablets.
2
Content available remote

Editors’ preface for the special issue “Recent advances in separation science”

63%
Tzanavaras P., Zacharis C.
Open Chemistry
|
2012
|
vol. 10
|
issue 3
415-416
3
Content available remote

Extraction of acyclovir from pharmaceutical creams for HPLC assay. Optimization and validation of pretreatment protocols

63%
Tzanavaras P., Zacharis C.
Open Chemistry
|
2008
|
vol. 6
|
issue 2
140-144
EN
Three simple protocols for the extraction of acyclovir from its pharmaceutical creams based on ultrasonication, ultrasonication with heating and magnetic stirring were evaluated and compared. Extraction kinetics were studied at different time intervals (5, 10, 15, 30 and 60 min) and the extraction efficiency was determined by HPLC. The effect of concentration of aqueous NaOH as the extraction medium and the stirring speed were also studied and optimized. Best results were obtained with 50 mL of 0.01 mol L−1 aqueous NaOH with magnetic stirring speed of 500 r.p.m. HPLC analysis involved rapid separation of acyclovir from the cream matrix using a 100 × 4.6 mm i.d. monolithic column and UV detection at 254 nm. Magnetic stirring produced the best results in terms of extraction efficiency with an average extraction yield of 100.8%, n = 16 at an optimum extraction time of 15 min. The selected protocol was validated for within and day-to-day precision and ruggedness. [...]
4
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Review of analytical methods for the determination of chlorine dioxide

51%
Tzanavaras P., Themelis D., Kika F.
Open Chemistry
|
2007
|
vol. 5
|
issue 1
1-12
EN
The present study reviews more than twenty years (1985-present) of published research on the development and application of analytical procedures for the determination of chlorine dioxide, a widely used disinfectant and bleaching agent. The review covers a variety of techniques including batch and automated spectrophotometry and fluorimetry, electroanalysis and chromatography. The analytical figures of merit to the methods are presented, while critical discussion regarding their advantages and disadvantages is addressed. [...]
5
Content available remote

Isocratic liquid chromatographic determination of three paraben preservatives in hygiene wipes using a reversed phase core-shell narrow-bore column

45%
Tzanavaras P., Karakosta T., Rigas P., Themelis D., Zotou A.
Open Chemistry
|
2012
|
vol. 10
|
issue 5
1459-1463
EN
The first HPLC method for the separation of three paraben preservatives (methyl-, ethyl- and propyl parabens) using a core-shell analytical column is reported in this study. The separation was completed in less than 8 min at a low flow rate of 0.4 mL min−1 and an isocratic mobile phase containing 20% acetonitrile as organic modifier. The backpressure was HPLC equipment. The proposed analytical procedure was validated for linearity (0.5–20 µg L−1), limits of detection (15–43 µg L−1) and quantification (50–142 µg L−1), selectivity, within day (1.3–1.5%) and day-to-day (3.4–4.6%) precision and accuracy. The proposed method has been applied to the determination of the selected paraben preservatives in commercially available hygiene wipes. The mean percent recoveries were found to be in the range of 98.0–98.4%. [...]
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