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Involvement of Free Radicals in the Ageing of Cutaneous Membrane

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Adetuyi B. O., Adebayo P. F., Olajide P. A., Atanda O. O., Oloke J. K.
World News of Natural Sciences
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2022
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vol. 43
11-37
EN
The free radical theory of aging suggests that aging is caused by accumulation of damage inflicted by reactive oxygen species (ROS). However, this concept has been very useful in defining the contribution of oxidative damage to the aging process, an increasing number of studies opposes it. The idea that oxidative damage represents only one of many causes of aging also has limitations, as it does not explain causal relationships and inevitability of damage accumulation. Here, it is discussed that heterogeneity, infidelity and imperfectness of each and every biological process may be responsible for the inevitable accumulation of by-products and other damage forms. Although ROS are prototypical by-products, their contribution to aging is governed by the metabolic organization of the cell, its protective systems, and genotype. These factors are controlled by natural selection, dietary and genetic interventions that extend lifespan, change the composition of cumulative damage and the rates of accumulation of its various forms. Oxidative damage, like other specific damage types viewed in isolation or in combination, does not represent the cause of aging. Instead, biological imperfectness, which leads to inevitable accumulation of damage in the form of mildly deleterious molecular species, may help define the true root of aging. Free radical and other specialized damage theories served their purpose in the understanding of the aging process, but in the current form they limit further progress in this area.
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Nutraceuticals: role in metabolic disease, prevention and treatment

86%
Adetuyi B. O., Odine G. O., Olajide P. A., Adetuyi O. A., Atanda O. O., Oloke J. K.
World News of Natural Sciences
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2022
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vol. 42
1-27
EN
Nutraceuticals are products that are also used as medicine other than nutrition. A nutraceutical product may be defined as a substance, which have physiological benefits nor gives protection against chronic diseases. Nutraceuticals may also be used to improve health, delay the aging process, prevent chronic disease, increase life expectancy, or support the structure or function of the body. Nowadays, nutraceuticals has gained considerable interest due to potential nutritional safety and therapeutic effects. Recent studies have shown promising results for those compounds in various complications. Emphasis has been made to present herbal nutraceuticals effective on hard curative disorders related to oxidative stress including allergy, Alzheimer, cardiovascular, cancer, diabetes, and Parkinson’s diseases as well as obesity.
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