Chronic, but not acute, electroconvulsive treatment reduced the immobility time of rats in the forced swimming test; nifedipine facilitated that effect.
A 7-day incubation of neuronal and glial cells with (2 myM) did not reduce cAMP response to or , however such an effect was observed when the cells were incubated with imipramine in the calcium channel antagonist nifedipine (1myM).
Nifedipine administered for either 10 or 28 dayz did not affect the cAMP response to noradrenalina or isoproterenol; however it decreased the inhibitory effect of ECS on the noradrenaline-stimulated cAMP generation.
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