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1

The application of cytochromes in pharmaceutical biotechnology

100%
Godawska A., Kie?-Kononowicz K.
Biotechnologia
|
2004
|
issue 3
166-183
EN
Cytochromes are enzymes which play very important role in human metabolism. These proteins contain hem as prostetic group. In vivo cytochromes are responsible for energy production and drug metabolism. Cytochromes occur in almost all human cells. Many classes of cytochromes are known but only four classes have been used in biotechnology so far. These are cytochrome c, cytochrome P-450, cytochrome b2 and cytochrome b5. Cytochrome c and cytochrome P-450 catalyse oxidizing reactions of organic compounds. These reactions are similar to the reactions which occur in human body.
2

The comparison of praziquantel biotransformation in silico and in vitro

81%
Godawska A., Pekala E., Kiec-Kononowicz K.
Biotechnologia
|
2005
|
issue 1
215-222
EN
Praziquantel (PZQ) is a drug which is used by choice to schistosomiasis treatment. Currently, it is used in malaria treatment. PZQ undergoes extensive metabolism in human body, mainly in liver, by two cytochrome P-450 isoenzymes 2B1 and 3A. As a result of these biotransformations, numerous mono- and dihydroxylated derivates in B, C and D rings are formed. Only one metabolite has been identified and described, it is 4-hydroxypraziquantel (4-OH-PZQ). So for, the metabolites out of PZQ biotransformation were obtained under the influence of Cunnighamelle echinulata and Beauveria bassiana. There were the derivatives in position C7 and in D-ring (position is unknown). In our research, we would like to create a new model of PZQ biotransformation in vitro. For such purpose, Saccharomyces cerevisiae were used. The results of PZQ biotransformation in vitro under the influence of Saccharomyces cerevisiae were compared with computer simulation of PZQ metabolism performed by the use of Metabol Expert program.
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