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1
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Przeciwnowotworowe działanie roślinnych triterpenoidów: kwasu oleanolowego i ursolowego oraz ich pochodnych

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Chojnicka I., Janiszowska W.
Kosmos
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2007
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vol. 56
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issue 3-4
335-341
EN
Oleanolic acid and ursolic acid occur widely in species of the /Magnoliopsydia/ class. They are classified as pentacyclic triterpenoids, which belong to a large group of compounds known as secondary metabolites. Glycoside derivatives of oleanolic and ursolic acids are saponins, so-called because of their ability to form in water a stable soapy foam. Oleanolic acid and ursolic acid as well as their derivatives reveal antioxidant, antimutagenic and cytotoxic activity. They prevent formation of cancer, inhibit tumor promotion, differentiation of cancer cells and angiogenesis. Therefore potentially they can be used in chemoprevention as well as in cancer therapy.
2
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Preliminary characterization of S-adenosylmethionine: tocopherol methyltransferase from chloroplasts of Calendula officinalis seedlings

100%
Michałowski M., Janiszowska W.
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vol. 40
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issue 1
116-119
3
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The effect of inorganic pyrophosphate on the transport of oleanolic acid monoglycosides into vacuoles isolated from Calendula officinalis leaves

100%
Szakiel A., Janiszowska W.
Acta Biochimica Polonica
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1998
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vol. 45
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issue 3
819-823
4
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Przeciwwirusowe działanie triterpenoidów roślinnych

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Plakwicz M., Janiszowska W.
Kosmos
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2008
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vol. 57
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issue 3-4
351-361
EN
One of the most interesting groups of secondary plant compounds are penta- and tetracyclic triterpenoids and their glycosides and glycosidoesters. They have a wide spectrum of pharmaceutical activities such as anti-inflammatory, anti-tumor, anti-mutagenic, cytotoxic, anti-hepatotoxic, anti-diabetic, antibacterial etc. This review summarises studies on antiviral activity of triterpenoids and their natural and synthetic derivatives. Possible mechanisms of pharmacological effects on human immunodeficiency virus (HIV) and herpes simplex virus type 1 (HSV-1) as well as the prospects for future applications of these compounds are discussed.
5
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Przeciwpasożytnicze działanie triterpenoidów roślinnych

100%
Markowski M., Janiszowska W.
Kosmos
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2015
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vol. 64
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issue 1
129-136
PL
Robaki pasożytnicze od zarania dziejów stanowiły istotny problem dla ludzkości. Pasożyty, zarówno płazińce (Platyhelmintes), jak i obleńce (Nematoda), powodują duże straty wśród zwierząt hodowlanych i ciągle infekują znaczną liczbę osób, zwłaszcza w krajach rozwijających się. Do tej pory niewiele jest znanych i stosowanych leków przeciwpasożytniczych, które dodatkowo wywołują niepożądane efekty uboczne, a pasożyty nabywają na nie oporności. Z tego powodu poszukiwane są nowe, naturalne substancje, które wykazywałyby właściwości przeciwpasożytnicze przy braku toksyczności. Takimi związkami mogłyby być roślinne triterpenoidy cykliczne, które często wykazują różne aktywności biologiczne. W artykule przedstawiono badania wykazujące, że niektóre triterpenoidy, zarówno wolne aglikony, glikozydy oraz glikozydoestry, wykazują aktywności przeciwko pasożytniczym nicieniom, tasiemcom, przywrom oraz przywrom skrzelowym.
EN
Helminth parasites have been always a major problem for humanity. Parasites - both flatworms (Platyhelmintes) and roundworms (Nematoda) cause large losses in livestock and are infecting vast number of people, especially in developing countries. Unfortunately, only few medicines are available for curing helminth infections; moreover, the available ones are not free of side effects and parasites develop tolerance toward them. This is why research interests are focused on the search of natural products of anthelmintic properties and lack of toxicity. Plant triterpenoids, known to possess various biological activities, may prove to belong to this class. This article presents results of studies showing that various forms of these compounds: free aglycone, glycosides and glycoside-esters possess anthelmintic activities against nematodes, cestodes, trematodes and Monogenea.
6
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Reversibility of the oleanolic acid monoglycosides transport across the tonoplast in vacuoles isolated from Calendula officinalis leaves

100%
Szakiel A., Janiszowska W.
Acta Biochimica Polonica
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1997
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vol. 44
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issue 1
55-59
7
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The effect of pH and ATP on the transport of oleanolic acid monoglycosides into isolatedvacuoles of Calendula officinalis leaves

100%
Szakiel A., Janiszowska W.
Acta Biochimica Polonica
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1991
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vol. 38
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issue 1
47-51
8
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The kinetics of transport of oleanolic acid monoglycosides into vacuoles isolated from Calendula officinalis leaf protoplasts

100%
Szakiel A., Janiszowska W.
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vol. 40
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issue 1
136-138
9
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Competition between oleanolic acid glycosides in their transport to isolated vacuoles from Calendula officinalis leaf protoplasts

100%
Szakiel A., Janiszowska W.
Acta Biochimica Polonica
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1992
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vol. 39
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issue 1
107-112
10
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Metabolism of [3-^3H]oleanolic acid in the isolated Calendula officinalis leaf cells and transport of the synthesized glycosides to the cell wall and the extracellular space

81%
Szakiel A., Wasiukiewicz I., Janiszowska W.
Acta Biochimica Polonica
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1995
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vol. 42
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issue 1
25-29
11
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Intracellular localization of labelling of tocopherols with [U-_14C]tyrosine in Calendula officinalis leaves

80%
Janiszowska W., Jasińska R.
Acta Biochimica Polonica
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1982
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vol. 29
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issue 1-2
37-44
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