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Znaczenie suplementacji w regulacji zaburzeń strukturalnych oraz funkcjonalnych w ośrodkowym układzie nerwowym u osób z zespołem Downa

100%
Narbutowicz M., Regulska-Ilow B.
Pediatria i Medycyna Rodzinna
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2017
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vol. 13
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issue 3
352-362
EN
Down syndrome is the most common genetic cause of intellectual disability in humans, which results from the presence of an extra chromosome 21. Significant progress has been made over the past years in expanding knowledge on molecular, structural and functional abnormalities in patients with Down syndrome. The obtained findings encouraged many scientists to attempt to use bioactive substances in in vivo and in vitro settings to inhibit central nervous system disorders. The use of supplements in the form of epigallocatechin gallate (EGCG) contributes to improved mitochondrial function in neurons, reduced DYRK1A overexpression and limited overproduction of reactive oxygen species. Certain doses of resveratrol improve mitochondrial function, increase hippocampal progenitor cell proliferation and, similarly to curcumin and pomegranate juice, inhibit premature ageing and prevent Alzheimer’s disease. Furthermore, it was observed that the use of choline supplements during pregnancy in healthy and trisomic experimental animals contributed to the stimulation of hippocampal neurogenesis, improved concentration, mood and cognitive functions in the offspring.
PL
Zespół Downa jest najczęstszą genetyczną przyczyną niepełnosprawności intelektualnej u ludzi, wynikającą z obecności dodatkowego chromosomu 21. W ciągu ostatnich kilku lat dokonano znacznego postępu w pogłębieniu wiedzy na temat zaburzeń na poziomie molekularnym oraz strukturalnym i funkcjonalnym narządów i układów u osób z zespołem Downa. Otrzymane wyniki badań skłoniły wielu naukowców do podjęcia prób zastosowania substancji bioaktywnych in vivo i in vitro w celu zahamowania zaburzeń w obrębie ośrodkowego układu nerwowego. Zastosowanie suplementów w postaci galusanu epigallokatechiny (epigallocatechin gallate, EGCG) przyczynia się do poprawy funkcjonowania mitochondriów w neuronach, obniżenia nadekspresji genu DYRK1A oraz ograniczenia nadprodukcji reaktywnych form tlenu. Przyjmowanie określonych dawek resweratrolu wpływa na poprawę funkcjonowania mitochondriów, zwiększenie proliferacji komórek progenitorowych w hipokampie oraz podobnie jak kurkumina i sok z granatu hamuje przedwczesne starzenie organizmu i zapobiega wystąpieniu choroby Alzheimera. Zaobserwowano ponadto, iż zastosowanie suplementów choliny w okresie ciąży u zwierząt doświadczalnych zdrowych i z trisomią przyczyniło się do stymulacji neurogenezy w hipokampie, poprawy koncentracji, nastroju oraz funkcjonowania procesów poznawczych u potomstwa.
2
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Evaluation of the relationship of the climbing level of sport climbers with selected anthropometric indicators and diet composition

81%
Przeliorz-Pyszczek A., Gołąbek K., Regulska-Ilow B.
Central European Journal of Sport Sciences and Medicine
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2019
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vol. 28
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issue 4
15-26
EN
Climbing is becoming more and more popular. During 2020 Olympic Games this discipline will be competed for the first time. Individualized diet plays a significant role among representatives of all sport disciplines. The aim of this research was to evaluate the correlation between the level of advancement of sport climbers, selected anthropometric indicators and diet composition. The study involved 36 women and 65 men practicing sport climbing who completed the food record and the survey on the most difficult climbing routes completed. Anthropometric measurements were collected. In the group of men statistically significant, positive correlation between the climbing level and the diet content of fiber, vitamin E, potassium, iron, zinc, and copper, was observed. In the group of women, a statistically significant positive correlation between the climbing level and the participation of vitamin C, potassium, magnesium and copper in the diet was observed. There was a positive correlation of protein, vitamin B2, B6, B12, D, phosphorus, magnesium, iron and copper content, and negative correlation between SFA content per 1,000 kcal of the diet and the climbing level of study participants. No statistical correlation was found between anthropometric parameters and advancement level.
3
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Dietary Intake of Antioxidant Vitamins in Diets of Amateur Adults Preparing For a Marathon

61%
Kosendiak A., Kawicka A., Różańska D., Konikowska K., Salomon A., Regulska-Ilow B.
Central European Journal of Sport Sciences and Medicine
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2015
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vol. 11
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issue 3
71-79
EN
The aim of this study was to evaluate the content of antioxidant vitamins in the diet of amateurs preparing for a marathon. The study group consisted of 92 women (30.8 ±6.7 years old) and 66 men (33.2 ±6.6 years old). Assessment of the content of antioxidant vitamins in the diet of the subjects was made on the basis of the 3-day dietary records. The average content of vitamin A in the diets of women surveyed was 1,296.8 mg/day and 1,499.7 mg/day in the diets of men. The vitamin A content of less than 90% of the norm was observed in the diets of 2.2% women and 9.1% men. The average content of vitamin C in the diet amounted to 130.6 (women) and 111.4 (men) mg/day. Significantly more men than women (30% vs 13%) did not fulfill the norm for vitamin C. The average vitamin E content was higher in the diets of men than in women (15.2 vs 13.0 mg/day; p < 0.0001). The vitamin E content was insufficient compared to norms in the diets of 10% of women and 12% of men. The average content of vitamins A, C and E in the diet of the subjects significantly exceeded the recommendations. The largest proportion of diets, not meeting the stated norms for vitamin C were in the group of men.
4
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DIETARY INTAKE OF MINERALS IN DIETS OF ADULTS PREPARING FOR MARATHON

61%
Salomon A., Mandecka A., Różańska D., Konikowska K., Kosendiak A., Regulska-Ilow B.
Central European Journal of Sport Sciences and Medicine
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2017
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vol. 18
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issue 2
23-32
EN
The aim of the study was to evaluate the mineral content in the diets of amateurs preparing for a marathon. The examined group consisted of 92 women (W), whose average age was 30.8 ±6.7 years and 66 men (M), whose average age was 33.2 ±6.6 years. The evaluation of the mineral content of the diets of the surveyed people was done using three-day dietary records which included one day of the weekend. The average daily sodium content in the diets of women was 1,952.2 ±729.2 mg, and in the diets of men it was 3,093.1 ±1,063.3 mg whereas potassium content was 3,361.6 ±798.5 mg and 3,900.3 ±982.3 mg respectively. The potassium content of less than 90% of fulfilling the norm was observed in the diets of 84.8% of women and 66.7% of men. The average content of calcium in the diets of women and men amounted to 887.5 ±278.8 mg and 1,162.6 ± 434.3 mg/day respectively. The diets of 30.4% of women and 16.7% of men had insufficient calcium content as compared to the norms. The average daily phosphorus and magnesium content was significantly higher in men than in women (1,374.6 ±348.6 vs 1,823.5 ±473.0 mg and 373.4 ±107.1 vs 423.6 ±108.8 mg). Magnesium intake was insufficient in the diets of 14.1% of women and 28.8% of men. The average daily content of iron, zinc and copper in the group of women was: 12.1 mg, 10.1 mg and 1.4 mg, while in the diets of men respectively 14.8 mg, 13.5 mg and 1.5 mg. The highest percentage of diets not fulfilling the norm was found for calcium and potassium in women, and potassium and magnesium for men.
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