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1

QUANTITATIVE ANALYSIS OF FLAVONOIDS AND PHENOLIC ACIDS FROM INFLORESCENCES AND AERIAL PARTS OF SELECTED CIRSIUM SPECIES USING ASE METHOD

100%

KOZYRA M., SKALICKA-WOŹNIAK K.

Acta Poloniae Pharmaceutica - Drug Research

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2014

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vol. 71

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issue 5

877-881

2

COMPARATVE URIC ACID LOWERING STUDIES OF ALLOPURINOL WITH AN INDIGENOUS MEDICINAL PLANT IN RABBITS

100%

MOHAMMAD I. S., LATIF S., YAR M., NASAR F., AHMAD I., NAEEM M.

Acta Poloniae Pharmaceutica - Drug Research

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2014

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vol. 71

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issue 5

855-859

EN

The aim of this research was to carry out a comparative study of lowering of uric acid by the use of dried powder of Colchicum luteum and allopathic drug (allopurinol) in rabbits, to determine whether herbal drugs can be used by patients instead of allopathic drugs. The herbal medicine, dried corm powder of Colchicum luteum 2.5 mg/kg/day and dried powder of allopurinol 2 mg/kg/day an allopathic medicine, was used in the study. The results of these medicines were observed in animal model, using 12 adult rabbits, which were divided into three groups A, B and C, respectively, where group C was taken as control. The SPSS version 17 was used for statistical analysis and analysis of variance (ANOVA) was used for comparing the data in different groups and the level of significance was 5%. It was resulted that dried corm of Colchicum luteum significantly reduced the uric acid in adult rabbits as reduced by allopathic medicine ñ allopurinol. In the light of present research we concluded that the herbal medicines can be used in lieu of allopathic drugs. Thus, the risk of side effects that are associated with the prolonged use of allopathic drugs can be minimized.

3

QUANTITATIVE STUDY EVALUATING PERCEPTION OF GENERAL PUBLIC TOWARDS ROLE OF PHARMACIST IN HEALTH CARE SYSTEM OF PAKISTAN

100%

JIN X., AZHAR S., MURTAZA G., XUE F., MUMTAZ A., NIU H., TAHA A., ZHANG Y.

Acta Poloniae Pharmaceutica - Drug Research

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2014

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vol. 71

|

issue 5

869-875

EN

To investigate general public perception towards the role of pharmacist in developing countriesí healthcare system was the main aim of this study, which would be the basic foundation for researching the treatment pattern of cognitive disorder after stroke in communities. The study population (sample size = 385) consisted of general public from Islamabad, Faisalabad and Lahore, Pakistan. Main sections of the questionnaire comprised of series of statements pertaining to consumerís perception and experience with the pharmacists. The response rate of study was 77.1%. A majority (80.1%) of the consumers knows who is pharmacist; 49.8% (n = 148) of the respondents found the pharmacist working in the pharmacies; 74.1% (n = 220) believed that pharmacist can guide them regarding their medicine. With respect to government efforts to improve services provided by community pharmacies, less percentage (31.0%) of the consumers were satisfied. Half of the respondents (59.9%) were expecting from the pharmacists to be knowledgeable drug therapy experts, whereas 61.3% (n = 182) expect from the pharmacists to educate them regarding safe and appropriate use of medication. The findings of this study conclude that the quality of pharmaceutical services provided is very low in Pakistan. There is a gap between the public and the pharmacist, which can only be filled by creating awareness among public regarding the pharmacistís role in healthcare system and by focusing on how services provided by the pharmacists can add improvement to general public health.

4

BIOEQUIVALENCE STUDY OF 400 AND 100 MG IMATINIB FILM-COATED TABLETS IN HEALTHY VOLUNTEERS

100%

OSTROWICZ A., MIKOŁAJCZAK P. Ł., WIERZBICKA M., BOGURADZKI P.

Acta Poloniae Pharmaceutica - Drug Research

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2014

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vol. 71

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issue 5

843-854

EN

The aim of the study was to investigate the bioavailability of a generic product of 100 mg and 400 mg imatinib film-coated tablets (test) as compared to that of a branded product (reference) at the same strength to determine bioequivalence. The secondary objective of the study was to evaluate tolerability of both products. An open-label, randomized, crossover, two-period, single-dose, comparative study was conducted in 43 (Imatynib-Biofarm 100 mg film-coated tablet) and in 42 (Imatynib-Biofarm 400 mg film-coated tablet), brand name Imatenil, Caucasian healthy volunteers in fed conditions. A single oral dose administration of the test or reference product was separated by 14-day washout period. The imatinib and its metabolite N-desmethyl imatinib concentrations were determined using a validated LC MS/MS method. The results of the single-dose study in healthy volunteers indicated that the film-coated tablets of Imatynib-Biofarm 100 mg and 400 mg film-coated tablets manufactured by Biofarm Sp. z o.o. (test products) are bioequivalent to those of Glivec 100 mg and 400 mg film-coated tablets manufactured by Novartis Pharma GmbH (reference products). Both products in the two doses of imatinib were well tolerated.

5

CARDIOPROTECTIVE EFFECT OF GREEN TEA EXTRACT ON DOXORUBICIN-INDUCED CARDIOTOXICITY IN RATS

100%

KHAN G., HAQUE S. E., ANWER T., AHSAN M. N., SAFHI M. M., ALAM M. F.

Acta Poloniae Pharmaceutica - Drug Research

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2014

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vol. 71

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issue 5

861-868

EN

The in vivo antioxidant properties of green tea extract (GTE) were investigated against doxorubicin (DOX) induced cardiotoxicity in rats. In this experiment, 48 Wistar albino rats (200ñ250 g) were divided into eight groups (n = 6). Control group received normal saline for 30 days. Cardiotoxicity was induced by DOX (20 mg/kg i.p.), once on 29th day of study and were treated with GTE (100, 200 and 400 mg/kg, p.o.) for 30 days. Aspartate aminotransferase (AST), creatinine kinase (CK), lactate dehydrogenase (LDH), lipid peroxidation (LPO), cytochrome P450 (CYP), blood glutathione, tissue glutathione, enzymatic and non-enzymatic antioxidants were evaluated along with histopathological studies. DOX treated rats showed a significant increased levels of AST, CK, LDH, LPO and CYP, which were restored by oral administration of GTE at doses 100, 200 and 400 mg/kg for 30 days. Moreover, GTE administration significantly increased the activities of glutathione peroxidase (GPX), glutathione reductase (GR), glutathione s-transferase (GST), superoxide dismutase (SOD) and catalase (CAT), in heart, which were reduced by DOX treatment. In this study, we have found that oral administration of GTE prevented DOX-induced cardiotoxicity by accelerating heart antioxidant defense mechanisms and down regulating the LPO levels to the normal levels.

6

CHITOSAN-DERIVATIVES IN COMBINATIONS WITH SELECTED PORPHYRINOIDS AS NOVEL HYBRID MATERIALS FOR MEDICINE AND PHARMACY

100%

Szczepański R., Gadomska L., Michalak M., Bakun P., Pawlak K., Goslinski T., Ziegler-Borowska M., Czarczynska-Goslinska B.

Progress on Chemistry and Application of Chitin and its Derivatives

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2020

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vol. 25

63 - 78

EN

Chitosan and its derivatives are renewable biopolymers characterized by high biocompatibility; therefore, they are harmless to humans and allow immune tolerance and improved hydrophilicity. Moreover, chitosan has been the most studied of all polysaccharides used in biomedical applications during the last decade. Combinations of chitosan and porphyrinoid compounds in hybrid materials have revealed many potential applications for biomedical sciences. The main advantage of such materials is an increase in the solubility of porphyrinoids in body fluids and therefore greater release of singlet oxygen to the treated tissue. Chitosan-based drug delivery systems can improve the targeting of porphyrinoids and their release at predetermined locations and finally achieve desired therapeutic effects with minimal side effects. Hence, porphyrinoid-chitosan materials can be applied in drug delivery systems, cancer theranostics and magnetic resonance imaging. The combination of chitosan and porphyrinoids also appears useful in the healing and repairing of damaged organs, tissue engineering, regenerative medicine, as well as dressing materials. Huge benefits are related to the treatment of wounds, which has been presented for self-healing hydrogels based on chitosan and porphyrinoids. Furthermore, the chitosan/porphyrinoid combinations have revealed enormous benefits for antimicrobial photodynamic therapy.

7

THE EXCIPIENTS USED IN THE NON-COATED TABLETS - A REVIEW

100%

POLSKI A., IWANIAK K., NALEŚNIAK M., POLESZAK E.

Medicina Internacia Revuo

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2014

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vol. 26

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issue 102

10-18

EN

In modern drug technology excipients fulfill many important roles: antiadherents, binders, disintegrants, fillers, flavours, lubricants, etc. They can modify many properties of tablets including disintegration time, substance release place (stomach, intestine) and time (fast or slow release, non-modified), improvement of taste and flavor, etc. There are many scientific reports that can help choose suitable excipients to produce tablets that have desired properties. That paper was created to arrange knowledge about them.

8

Chronic effects of and on the beta-adrenergic function in neuronal and glial

100%

Legutko B., Frankiewicz T., Czyrak A., Pilc A.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 2

213-218

EN

A 7-day incubation of neuronal and glial cells with (2 myM) did not reduce cAMP response to or , however such an effect was observed when the cells were incubated with imipramine in the calcium channel antagonist nifedipine (1myM).

9

Antidepressant-like and anxiolytic-like activity of a novel indoleamine derivative ADN -2013 in rodents

100%

Wasik A., Partyka A., Jastrzębska-Więsek M., Kołaczkowski M., Wesołowska A.

Medicina Internacia Revuo

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2017

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vol. 28

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issue 108

152-162

EN

A novel indolamine derivative, ADN-2013, has been proved to possess a preclinical activity profile appropriate for the treatment of behavioral and psychological symptoms of dementia. Its antidepressant and anxiolytic properties have been examined in rat and mice models. The receptor mechanisms underlying the antidepressant properties of ADN-2013 have also been elucidated. ADN-2013 significantly shortened the immobility time measured in the forced swim test in mice and rats, producing an effect that was abolished by the dopamine D1-receptor antagonist SCH 23390 in rats. Moreover, ADN-2013 evoked anxiolytic-like activity in both “conditional” and “unconditional” anxiety-like paradigms in mice and rats. From these results, it is likely that direct antagonism toward serotonin 5-HT6 receptors and an indirect effect of dopamine, acting mostly via D1-like receptors, may be involved in the antidepressant action of ADN-2013. However, the partial agonist activity of ADN-2013 toward D2 receptors, observed in in vitro studies, might also contribute to this effect.

10

STUDIES OF GENTAMYCIN ADSORPTION ON CHITOSAN

100%

Meler J., Grimling B., Pluta J.

Progress on Chemistry and Application of Chitin and its Derivatives

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2013

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vol. 18

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issue 18

175-179

EN

Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind gentamycin. The aim of the study was to determine the binding capability of Gentamycin by chitosan’s contained in weight-loss supplements. The Gentamycin absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of gentamycin by chitosan ranged from 2,1% to 34,1% depending on the environmental pH. The highest absorption rate was observed at above pH 6,8. Concluding, the studies confirmed that the investigated gentamycin interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.

11

THE USE OF CHITIN AND CHITOSAN IN MANUFACTURING DRESSING MATERIALS

100%

Latańska I., Kolesińska B., Draczyński Z., Sujka W.

Progress on Chemistry and Application of Chitin and its Derivatives

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2020

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vol. 25

16 - 36

EN

Despite continuous progress in the development of advanced dressing materials, there is a constant need for dressings used in an environment of infected and hard-to-heal wounds. Dressings that meet the above described requirements are products based on chitin and its derivatives. Chitosan and chitin derivative dressings are now becoming a very effective medical device in healing hard-to-heal wounds, as well as in the control of severely bleeding wounds. Chitosan and chitin are particularly valuable raw materials that accelerate wound healing processes, and they are also biocompatible and antibacterial. Dressings made of butyric-acetic chitin copolyester are intended for treating wounds of various aetiologies, including chronic wounds in which the healing process is disturbed by concomitant diseases. Materials based on chitosan are also widely used in the area of heavily bleeding and chronic wounds.

12

Nepafenak w praktyce lekarza okulisty – co decyduje o jego skuteczności i bezpieczeństwie stosowania?

100%

Woroń J.

OphthaTherapy

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2019

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vol. 6

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issue 1

39-42

EN

In the treatment of inflammatory eye diseases, the ophthalmologist often has to face a difficult choice of pharmacological treatment strategies. It is worth remembering that the available ophthalmic drugs may differ substantially from one another, hence it is important to take into account the pharmacokinetic- pharmacodynamic profile of the drugs used. Different mechanisms of action as well as different tolerance of topically applied drugs can affect both the effectiveness and safety of the treatment.

PL

W terapii zapalnych chorób narządu wzroku okulista staje niejednokrotnie przed niełatwym wyborem strategii leczenia farmakologicznego. Warto pamiętać, że dostępne leki okulistyczne mogą zasadniczo różnić się między sobą, stąd tak istotne jest uwzględnienie profilu farmakokinetyczno-farmakodynamicznego stosowanych leków. Odmienne mechanizmy działania, a także różna tolerancja miejscowo stosowanych leków mogą wpływać zarówno na efektywność, jak i bezpieczeństwo leczenia.

13

The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

100%

Wisniewski K., Borawska M., Car H.

Polish Journal of Pharmacology

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1993

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vol. 45

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issue 1

23-29

EN

Angiotensin II (1-8) (A II) and its fragments: angiotensin III (2-8) (A III), angiotensin IV (3-8) (A IV), angiotensin V (4-8) (A V) and angiotensin VI (3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.

14

Psychotropic effects of angiotensin II N-terminal fragments in rats

100%

Holy Z., Braszko J., Wisniewski K.

Polish Journal of Pharmacology

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1993

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vol. 45

|

issue 1

31-41

EN

In this study the effects of angiotensin (AII) angiotensin II hexapeptide [AII(1-6)] and angiotensin II pentapeptide [AII(2-6)] on the motility, stereotypy, learning of conditioned avoidance responses (CARs) and recall of a passive behavior making it possible to avoid averisve stimulation in rats, were compared. All the peptides were injected into the lateral cerebral ventrice (icv) in a dose of 1nmol. AII caused a statistically significant increase in the number of crossings, rearings, and bar approaches in an open field whereas [AII(1-6)] and [AII(2-6)] were inactive in this test. The stereotypic behavior induced by an intraperitoneal (ip) injection of apomorphine (1mg/kg) and amphetamine (7,5 mg/kg) was statistically significantly enhanced only in the rats wihich received AII icv. The application of AII, but not that of [AII(1-6)] and [AII(2-6)] resulted in a quicker acquisition of the CARs. A better recall of passive avoidance was achieved only by AII, while the fragments [AII(1-6)] and [AII(2-6)] had no effect. These findings indicate that the 1-6 and 2-6 fragments of AII do not possess a psychotropic activity like that of the parent ictapeptide.

15

Polymerization of Sickle Cell Disease and Methaeglobin in the Presence of Paracetamol

100%

Ihenetu S. C., Ikpa C. B. C., Igbokwe W. U., Okeke C. J., Ibe F. C.

World News of Natural Sciences

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2022

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vol. 43

96-107

EN

This study was designed to examine the Level of Polymerization of Sickle Cell Disease and Methaeglobin in the Presence of Paracetamol, the research was carried out using standard procedures. The present study has shown the level of polymerization of sickle cell disease and methaemoglobin in the presence of paracetamol. Within the experimental time of 30-180 seconds, the relative polymerizations range between the following; 70.43 ± 0.87 to 72.10 ± 0.37 at the control (0 mg/dl), at 50 mg/dl, there was an increase from 65.78 ± 0.89 to 69.47±1.00, at 100 mg/dl there was an increase in the polymerization from 68.96 ± 0.99 to 72.33 ±1.02, at 200 mg/dl there was an increase in the polymerization from 65.96 ± 69.26 ± 1.00 and at 500 mg/dl, there was an increase in the polymerization form 66.05 ± 0.98 to 69.42 ± 0.92. This increase in polymerization can be said to be due to the increase in the absorbance of paracetamol. However, the absorbance of the polymerization mixture in the presence of the malarial drug was not significantly different (p < 0.05) from the control sample at the 30 second. The present study showed that the level of polymerization of Hemoglobin S (HbS) molecules was attenuated upon the introduction of the anti-malarial drugs in the polymerizing mixture. The percentage of methaemoglobin increases with the increase in concentration of paracetamol from 2.77 ± 0.05 to 3.30 ± 0.03 starting from 0 mg/dl to 500 mg/dl concentration.

16

The action of antidepressant drugs administered during calcium channel blockade

100%

Vetulani J.

Polish Journal of Pharmacology

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1993

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vol. 45

|

issue 2

179-184

EN

This is an overview of the symposium concerned with the action of electroconvulsive treatment and some antidepressant drugs (mainly imipramine) applied during blockade of voltage-dependent calcium channels with nifedipine. The results in general suggest that a combination of calcium channel blockers with antidepressant drugs of ECT may be of clinical value in treatment of depression.

17

Influence of acetaldehyde on some serotonergic mechanism in rat blood platelets

100%

Pawlak D., Chabelska E., Buczko W.

Polish Journal of Pharmacology

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1993

|

vol. 45

|

issue 1

59-66

EN

Acetaldehyde (ACT), both, ex vivo and in vitro did not change the ADP-induced rat platelet aggregation and the potentiating action of serotonin. The whole blood serotonin content was decreased only when ACT was used in doses of 20 and 30 mg/kg, iv and the platelet serotonin content remained unchanged. Ex vivo, ACT had no influence on the labeled serotinin uptake, whereas in experiments in vitro it inhibited the amine uptake and augmented the serotonin release from blood platelets in a dose dependent manner. The results indicate that all the changes in the platelet serotonergic mechanisms appear only after high concentrations of ACT. They may be of significant importance in the circulatory system or hemostasis only during disulfiram or calcium carbamide therapy.

18

Nitric oxide donors as generators and scavengers of superoxide anions

100%

Robak J., Gryglewski R. J.

Polish Journal of Pharmacology

|

1993

|

vol. 45

|

issue 1

51-58

EN

Three classical direct nitric oxide (NO) donors, 3-morpholine-sydnonimine (SIN-1), S-nitroso-N-acetyl-d, 1-penicillamine (SNAP) and sodium nitroprusside (NaNP) as well as two indirect NO donors, molsidomine (MSL) and glyceryl trinitrate (GTN) were studied for their potencies to generate superoxide anions,to scavenge superoxide anions, to consume molecular oxygen and to inhibit . Out of five NO donors only those which were spontaneous releasers of NO at physiological pH were also scavengers of superoxidase anions which has been generated by xanthine: xanthine oxidase system (SIN-1 IC50 19 ?M, SNAP IC50 416 ?M) and inhibitors of the Fe3+ and ascorbate stimulated oxidation of rat liver lipids (SIN-1 IC50 76 ?M, SNAP IC50 12 ?M). Only SIN-1 at high concentrations of 300-5000 yM generated superoxidase anions as detected by a SOD inhibitable reduction of nitroblue tetrazolium. None of the in vitro studied activities were exerted by NaNP, MLS and GTN.

19

Evaluation of phytochemical, analgesic, acute toxicity and moisture content of Cumin cyminum

100%

Azubugwu C. M., Feridious N., Mostafa F., Ahmed B.

World News of Natural Sciences

|

2024

|

vol. 52

82-97

EN

The purpose of this study was to evaluate the analgesic, phytochemical screening, acute toxicity, and moisture content activity of the crude ethanolic seed extract of Cuminum cyminum and its n-hexane, chloroform, carbon tetrachloride and aqueous fraction. The ethanolic extract was used to the moisture content was found 43% evaluate analgesic, phytochemical screening, and moisture content activities. The analgesic activity was measured by acetic acid induced writhing test. The extract showed highly significant (p <0.001) analgesic activity with % inhibitions of writhing response at doses 250 mg/kg was 24.67% and 500 mg/kg was 36.95%. The moisture content was found to be 43%. The results of the study clearly indicate the present of analgesic, phytochemical screening and moisture content properties of the extract and its fractions. Phytochemical analysis revealed the presence of alkaloids, saponins, phenols, terpenoids and glycosides. Screening of analgesic property on mice by acetic acid induced method for crude extracts and its different fractions of Cuminum cyminum. At zero-hour test samples, control (1% Tween-80 solution in saline) and Diclofenac sodium were administered orally by means of a long needle with a ball shaped end. After 40 minutes acetic acid (1%) was administered intra- peritoneally to each of the animals of all the groups. The forty minutes interval between the oral administration of test materials and intra-peritoneal administration of acetic acid was given to assure proper absorption of the administered samples. Five minutes after the administration of acetic acid, number of squirms or writhing were counted for each mouse for ten minutes. Each mouse of all groups was observed individually for counting the number of writhing they made in 15 minutes commencing just 5 minutes after the Intra-peritoneal administration of acetic acid solution. Full writhing was not always accomplished by the animal, because sometimes the animals started to give writhing but they did not complete it. This incomplete writhing was considered as half-writhing. Accordingly, two half writhing were taken as one full writhing. In conclusion the ethanolic extract of C. cyminum seeds showed predominately showed significant analgesic activity.

20

The effect of chronic treatment with imipramine, ECS and nifedipine on the beta-andrenergic function in the rat hippocampal slices

100%

Frankiewicz T., Legutko B., Czyrak A., Pilc A.

Polish Journal of Pharmacology

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1993

|

vol. 45

|

issue 2

207-212

EN

Nifedipine administered for either 10 or 28 dayz did not affect the cAMP response to noradrenalina or isoproterenol; however it decreased the inhibitory effect of ECS on the noradrenaline-stimulated cAMP generation.

Refine search results

QUANTITATIVE ANALYSIS OF FLAVONOIDS AND PHENOLIC ACIDS FROM INFLORESCENCES AND AERIAL PARTS OF SELECTED CIRSIUM SPECIES USING ASE METHOD

COMPARATVE URIC ACID LOWERING STUDIES OF ALLOPURINOL WITH AN INDIGENOUS MEDICINAL PLANT IN RABBITS

QUANTITATIVE STUDY EVALUATING PERCEPTION OF GENERAL PUBLIC TOWARDS ROLE OF PHARMACIST IN HEALTH CARE SYSTEM OF PAKISTAN

BIOEQUIVALENCE STUDY OF 400 AND 100 MG IMATINIB FILM-COATED TABLETS IN HEALTHY VOLUNTEERS

CARDIOPROTECTIVE EFFECT OF GREEN TEA EXTRACT ON DOXORUBICIN-INDUCED CARDIOTOXICITY IN RATS

CHITOSAN-DERIVATIVES IN COMBINATIONS WITH SELECTED PORPHYRINOIDS AS NOVEL HYBRID MATERIALS FOR MEDICINE AND PHARMACY

THE EXCIPIENTS USED IN THE NON-COATED TABLETS - A REVIEW

Chronic effects of and on the beta-adrenergic function in neuronal and glial

Antidepressant-like and anxiolytic-like activity of a novel indoleamine derivative ADN -2013 in rodents

STUDIES OF GENTAMYCIN ADSORPTION ON CHITOSAN

THE USE OF CHITIN AND CHITOSAN IN MANUFACTURING DRESSING MATERIALS

Nepafenak w praktyce lekarza okulisty – co decyduje o jego skuteczności i bezpieczeństwie stosowania?

The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

Psychotropic effects of angiotensin II N-terminal fragments in rats

Polymerization of Sickle Cell Disease and Methaeglobin in the Presence of Paracetamol

The action of antidepressant drugs administered during calcium channel blockade

Influence of acetaldehyde on some serotonergic mechanism in rat blood platelets

Nitric oxide donors as generators and scavengers of superoxide anions

Evaluation of phytochemical, analgesic, acute toxicity and moisture content of Cumin cyminum

The effect of chronic treatment with imipramine, ECS and nifedipine on the beta-andrenergic function in the rat hippocampal slices