Non-steroidal anti-inflammatory drugs (NSAIDs) are connected with the generation of free radicals and one of its adverse effects is gastric ulceration. Ulceration was induced orally using aspirin. Twenty-four male Wistar rats were used for this study (120-150g). Rats were divided into 6 groups with each group containing 4 rats. Rats were pre-treated orally with cimetidine, a reference drug. Group 1 rats orally received 1% gum acacia solution as the control group, Group 2 rats orally administered 25 mg/kg aspirin and served as the ulcerated, untreated group, rats in groups 3 and 4 were pre-treated orally with 200 mg/kg and 400 mg/kg respectively for 3 days while rats in groups 5 and 6 were pre-treated orally with 50 mg/kg cimetidine and 50 mg/kg catechin respectively for 3 days. The result of this study shows that the ulcerated, untreated rats showed increased concentrations of gastric volume with a concomitant decrease in protein concentration compared to the control group, cimetidine and catechin reversed these observations. Activities of glutathione, catalase were decreased in the ulcerated, untreated group but pre-treatment with different doses, cimetidine and catechin reversed these observations. In conclusion, the ethanoic extract of L. aestuans can be said to be used as an anti-ulcerogenic agent against aspirin-induced gastric ulcer which is due to the presence of phytochemicals in the plant.
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.