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1

Role of the Wnt/beta-catenin network in regulating hematopoies

100%
Wilusz M., Majka M.
Archivum Immunologiae et Therapiae Experimentalis
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2008
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vol. 56
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issue 4
257-266
EN
The Wnt/ beta -catenin pathway plays a significant role in several aspects of cell biology, including the stimulation of gene expression, growth, and mobility. Wnt proteins activate at least three cascades: Wnt/ beta-catenin, Wnt/Ca2+, and planar cell polarity. beta-Catenin is not only a very important element of many intracellular signaling pathways, including the Wnt pathway, but it also takes part in creating intercellular adhesive junctions. When overexpressed or mutated it functions as an oncogen. The Wnt/ beta-catenin signaling pathway has been shown to play an important role in controlling the proliferation, survival, and differentiation of hematopoietic cells. Thus any aberrant signaling through this pathway may have a negative influence on hematopoiesis. Indeed, some recent findings suggest that Wnt/beta-catenin signaling is dysregulated in leukemias and lymphomas. All these data position the Wnt/beta-catenin signaling network as a critically important regulator of hematopoiesis and justify future efforts to better understand its role in the process of physiological and pathological hematopoiesis. The present review summarizes recent advances in this field.
2
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Superconducting Fault Current Limiter for the Electric Power System

100%
Majka M., Kozak J.
Acta Physica Polonica A
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2016
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vol. 130
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issue 2
581-584
EN
Superconducting fault current limiters are the most attractive devices for the power network, they can be used to limit the short current in electrical network. The operation of a superconducting fault current limiter is based on the sudden transition from the superconducting state to the normal state by exceeding the critical current I_{c} of the material. This transition one takes a very short time, so fast that we are able to limit the first current peak to a threshold value which does not exceed three to five times the rated current. This paper presents the design, the calculated electrical parameters and tests of the medium voltage class superconducting fault current limiter prototypes made in Electrotechnical Institute. The constructed coreless superconducting fault current limiter consists of three windings: ones made of SF12050 tape and a parallel connected primary copper winding. All windings are inductively coupled and intended to work in liquid nitrogen.
3
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Superconducting Devices for Power Engineering

61%
Janowski T., Kondratowicz-Kucewicz B., Wojtasiewicz G., Kozak S., Kozak J., Majka M., Jaroszyński L.
Acta Physica Polonica A
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2016
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vol. 130
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issue 2
537-544
EN
The paper presents the current state of research on superconducting devices for the electrical power system, i.e. transformers, fault-current limiters, and energy storages. In particular, it describes scientific achievements of the Laboratory of Superconducting Technologies of Electrotechnical Institute. The development of distributed and renewable energy sources, as well as the increasing number of receivers with low power factor will rise interest in superconducting fault-current limiters and superconducting transformers rated below 1 MVA. Previous studies were focused on the largest power transformers and highest current superconducting fault-current limiters. ReBCO coated conductors allow to build efficient superconducting AC devices. Superconducting tape of a layered structure (second generation HTS tape) enables the construction of transformer rated up to a few MVA without the usage of parallel conductors. Relatively high resistance of the tape in normal state allows to build fault-current limiters and fault-current limiting transformers. Superconducting transformers and superconducting fault-current limiters can help to increase connected power of distribution stations and thereby accelerate development of renewable energy sources.
4

The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner

52%
Kucia M., Wojakowski W., Reca R., Machalinski B., Gozdzik J., Majka M., Baran J., Ratajczak J., Ratajczak M. Z.
Archivum Immunologiae et Therapiae Experimentalis
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2006
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vol. 54
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issue 2
121-135
EN
Introduction: Recently we identified in bone marrow (BM) by employing chemotactic isolation to SDF-1 gradient combined with real time RT-PCR analysis a mobile population of CXCR4+ BM mononuclear cells that express mRNA for various markers of early tissue-committed stem cells (TCSCs). In this study we evaluated whether TCSCs respond to other moto-morphogens, such as hepatocyte growth factor (HGF) and leukemia inhibitory factor (LIF). Materials and Methods: We again employed chemotactic isolation combined with real-time RT-PCR analysis to assess whether murine and human BM contain TCSCs that respond to HGF and LIF gradients. We also evaluated expressions of HGF and LIF in damaged organs. Results: We noted that the number of TCSCs is highest in BM from young (1- to 2-month-old) mice and decreases in 1-year-old animals. Murine and human TCSCs 1) respond to HGF and LIF gradients in addition to an SDF-1 gradient, 2) reside in populations of BM-derived non-hematopoietic CD45? cells, and 3) are released (mobilized) from BM into the peripheral blood (PB) during tissue injury (e.g. after partial body irradiation). Conclusions: These findings further support our theory of the BM as a ?hideout' for TCSCs and we suggest that their presence in BM tissue should be considered before experimental evidence is interpreted simply as transdifferentiation/plasticity of hematopoietic stem cells. Since we demonstrated that not only SDF-1, but also HGF and LIF are upregulated in damaged tissues, we postulate that CXCR4+ c-Met+ LIF-R+ TCSC could be mobilized from the BM into the PB, from which they are subsequently chemoattracted to damaged organs, where they play a role in tissue repair/regeneration.
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