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The role of membrane glycoproteins CD46, CD55 and CD59 in protection of tumor cells against complement lysis

100%

Wojnicz D., Bar J., Jankowski S.

Postępy Higieny i Medycyny Doświadczalnej

2002

vol. 56

issue 5

603-616

Utilization of the complement system offers potential for the elimination of tumor cells by monoclonal antibodies (mAb) immunotherapy. Activation of the complement system causes tumor cell destruction by inducing complement lysis and promoting cell ? mediated killing. In addition, complement can induce a strong inflammatory response, which might enhance other antitumor effector mechanisms. An important targets for mAb immunotherapy, however, are membrane bound complement regulatory glycoprotein: CD46, CD55 and CD59, which have been found to be expressed on most tumor cells in vivo and in vitro. Blocking or downregulation of these inhibitors could be an important step in the advancement of mAb immunotherapy.

Ultrathin NbN Films for Superconducting Single-Photon Detectors

52%

Słysz W., Guziewicz M., Borysiewicz M., Domagała J., Pasternak I., Hejduk K., Rzodkiewicz W., Ratajczak J., Bar J., Węgrzecki M., Grabiec P., Grodecki R., Węgrzecka I., Sobolewski R.

Acta Physica Polonica A

2011

vol. 120

issue 1

200-203

We present our research on fabrication and structural and transport characterization of ultrathin superconducting NbN layers deposited on both single-crystal Al_2O_3 and Si wafers, and SiO_2 and Si_3N_4 buffer layers grown directly on Si wafers. The thicknesses of our films varied from 6 nm to 50 nm and they were grown using reactive RF magnetron sputtering on substrates maintained at the temperature 850°C. We have performed extensive morphology characterization of our films using the X-ray diffraction method and atomic force microscopy, and related the results to the type of the substrate used for the film deposition. Our transport measurements showed that even the thinnest, 6 nm thick NbN films had the superconducting critical temperature of 10-12 K, which was increased to 14 K for thicker films.

Technology of Ultrathin NbN and NbTiN Films for Superconducting Photodetectors

52%

Guziewicz M., Slysz W., Borysiewicz M., Kruszka R., Sidor Z., Juchniewicz M., Golaszewska K., Domagala J., Rzodkiewicz W., Ratajczak J., Bar J., Wegrzecki M., Sobolewski R.

Acta Physica Polonica A

2011

vol. 120

issue 6A

A-76-A-79

We report fabrication and characterization of ultrathin NbN and NbTiN films designed for superconducting photodetectors. Our NbN and NbTiN films were deposited on Al_2O_3 and Si single-crystal wafers by a high-temperature, reactive magnetron sputtering method and, subsequently, annealed at 1000°C. The best, 18 nm thick NbN films deposited on sapphire exhibited the critical temperature of 15.0 K and the critical current density as high as ≈ 8 × 10^6 A/cm^2 at 4.8 K.

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2 Acta Physica Polonica A

1 Postępy Higieny i Medycyny Doświadczalnej

2 2011

1 2002

3 Bar J.

2 Borysiewicz M.

2 Guziewicz M.

2 Ratajczak J.

2 Rzodkiewicz W.

2 Sobolewski R.

1 Domagala J.

1 Domagała J.

1 Golaszewska K.

1 Grabiec P.

1 Grodecki R.

1 Hejduk K.

1 Jankowski S.

1 Juchniewicz M.

1 Kruszka R.

1 Pasternak I.

1 Sidor Z.

1 Slysz W.

1 Słysz W.

1 Wegrzecki M.

1 Wojnicz D.

1 Węgrzecka I.

1 Węgrzecki M.

Search results

The role of membrane glycoproteins CD46, CD55 and CD59 in protection of tumor cells against complement lysis

Ultrathin NbN Films for Superconducting Single-Photon Detectors

Technology of Ultrathin NbN and NbTiN Films for Superconducting Photodetectors