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Novel nociceptin analogues.

100%

Bartosz-Bechowski H., Międzybrodzki R., Szymaniec S.

2001

vol. 48

issue 4

1155-1158

A series of new nociceptin analogues containing cysteine was tested for their nociceptive effects in tail-flick test on mice after icv injection. The cysteines were introduced in order to get irreversibly binding analogues based on the assumption that the cysteines in the ligand can interact with the cysteines from the receptor to form an S-S bridge. In vivo tests revealed that Cys1-nociceptin (1-13)-NH2 (Cys1-NC) is an antagonist, whereas Cys7-NC is an agonist. Gly1,[Phe(p-NO2)]4-NC was less active indicating that the antagonist properties of Cys1-NC are associated with the presence of the sulfhydryl group of cysteine. The analogues D-Cys2 and Cys3 were also almost inactive.

Hydrate of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulo-2,6-pyranose as new crystalline reagent in the preparation of Amadori derived peptides

76%

Stefanowicz P., Batorska J., Kijewska M., Bartosz-Bechowski H., Szewczuk Z., Lis T.

Open Chemistry

2010

vol. 8

issue 1

28-33

We established, that crystalline hydrate of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulo-2,6-pyranose is a new, convenient and stable reagent for solid phase synthesis of peptide derived Amadori products. The structure of the title compound was studied by X-ray analysis, NMR spectroscopy, and high resolution ESI-MS. The crystal structure indicated the existence of two symmetry-independent molecules that were not connected with hydrogen bonds. A comparison with previously reported 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose revealed, that these two compounds are isostructural. [...]

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1 Acta Biochimica Polonica

1 Open Chemistry

1 2010

1 2001

2 Bartosz-Bechowski H.

1 Batorska J.

1 Kijewska M.

1 Lis T.

1 Międzybrodzki R.

1 Stefanowicz P.

1 Szewczuk Z.

1 Szymaniec S.

Search results

Novel nociceptin analogues.

Hydrate of 2,3:4,5-di-O-isopropylidene-β-D-arabino-hexos-2-ulo-2,6-pyranose as new crystalline reagent in the preparation of Amadori derived peptides