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1

Molecular and cellular basis of interactions

100%
Zastawny T. H., Olinski R.
Postępy Higieny i Medycyny Doświadczalnej
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1993
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vol. 47
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issue 2
101-121
EN
Cis-DDP is an with activity against various . It is generally accepted that is the of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eucariotic systems. We also discuss the possible mechanisms of acquired of to cis-DDP and analoques, and potential clinical implication of this fenomenon.
2
Content available remote

Radiation induced oxidative DNA base damage and its repair in liver chromatin DNA of rats upon whole body γ-irradiation

81%
Zastawny T. H., Czerwińska B., Drzewiecka B., Oliński R.
Acta Biochimica Polonica
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1996
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vol. 43
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issue 3
579-582
3
Content available remote

Fractionation of DNA isolated from lymphocytes of patients under therapy with the antiblastic drug cis-diamminedichloroplatinum(II) using pulsed field gel electrophoresis

81%
Jaruga P., Zastawny T. H., Tujakowski J., Oliński R.
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vol. 40
|
issue 1
60-62
4
Content available remote

Repair of γ-ray-induced base damage in L5178Y sublines is damage type-dependent and unrelated to radiation sensitivity.

81%
Kruszewski M., Zastawny T. H., Szumiel I.
|
2001
|
vol. 48
|
issue 2
525-533
EN
The L5178Y (LY) murine lymphoma sublines LY-R and LY-S are differentially sensitive to ionizing radiation. The high radiation sensitivity of LY-S cells is related to impaired rejoining of DNA double strand breaks. We found previously that the γ-ray-induced base damage is higher in the more radiosensitive LY-S subline. Here, we examine the role of the repair of ionizing radiation induced base damage in relation to the radiosensitivity difference of these sublines. We used the GS/MS technique to estimate the repair rates of six types of base damage in γ-irradiated LY cells. All modified DNA bases identified in the course of this study were typical for irradiated chromatin. The total amount of initial base damage was higher in the radiation sensitive LY-S subline than in the radiation resistant LY-R subline. The repair rates of 5-OHMeUra, 5-OHCyt, 8-OHAde were similar in both cell lines, the repair rates of FapyAde and 8-OHGua were higher in the radiosensitive LY-S cell line, whereas the repair of 5-OHUra was faster in its radioresistant counterpart, the LY-R Altogether, the repair rates of the γ-ray-induced DNA base damage in LY sublines are related neither to the initial amounts of the damaged bases nor to the differential lethal or mutagenic effects of ionizing radiation in these sublines.
5
Content available remote

Cis-DDP induced alteration of DNA structure studied by scanning tunneling microscopy

80%
Zastawny T. H., Olejniczak W., Oliński R.
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|
vol. 40
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issue 4
555-558
6
Content available remote

The role of -SH groups in the resistance of E. coli cells to cis-diamminedichloroplatinum(II) (cis-DDP)

80%
Zastawny T. H., Oliński R.
|
|
vol. 40
|
issue 1
48-50
7
Content available remote

Investigation of DNA structures with scanning tunneling microscope

71%
Oliński R., Zastawny T. H., Olejniczak W., Wojczuk S., Chwiałkowski M.
Acta Biochimica Polonica
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1992
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vol. 39
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issue 1
15-19
8
Content available remote

Mutagenic specificity of imidazole ring-opened 7-methylpurines  in m13mp18 phage DNA

61%
Tudek B., Grąziewicz M., Kazanova O., Zastawny T. H., Obtułowicz T., Laval J.
Acta Biochimica Polonica
|
1999
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vol. 46
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issue 3
785-799
9
Content available remote

Oxidative DNA base modifications as factors in carcinogenesis

60%
Olinski R., Jaruga P., Zastawny T. H.
Acta Biochimica Polonica
|
1998
|
vol. 45
|
issue 2
561-572
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