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Effects of Growth Hormone Therapy and Physical Exercise on Anaerobic and Aerobic Power, Body Composition, Lipoprotein Profile in Middle Aged Men

100%

Zajâc A., Czuba M., Poprzecki S., Waśkiewicz Z., Cholewa J., Pilch J., Chycki J.

Journal of Human Kinetics

2010

vol. 25

67-76

Recently growth hormone therapy has been used as an age delaying drug in middle aged men and women as well as in the elderly. Positive effects have been shown in regards to body mass and body composition changes, fat metabolism, bone mineral density and muscle strength. Exercise is a potent physiological stimulus for growth hormone secretion and both aerobic and resistance exercise results in significant, acute serum increases in GH concentration. It is unclear however whether a combination of exercise and hGH therapy further increases physical performance in adults and increases changes in body composition and biochemical variables related to health. For this purpose a group of 15 middle aged men (45,7±5,8 years, 93,2±16,3kg and 183,3±4cm), slightly overweight were randomly divided into an experimental and control groups. Both groups exercised for 3 month, performing 2 aerobic sessions per week and 2 resistance workouts, increasing training loads every two weeks. The experimental group received additionally hGH subcutaneous injections beginning with 0,2 IU daily for the first month and then increasing it to 0,4 and 0,6 IU in successive month. VO2max was evaluated during a progressive ergocycle test to volitional exhaustion, while anaerobic power and capacity were measured during the 30s Wingate test. Additionally body mass and body composition were evaluated as well as the lipoprotein profile and the concentration of chosen anabolic hormones. The results indicate a significant rise in resting concentrations of GH and IGF-1 after the replacement therapy but no additional benefits in regards to aerobic fitness and fat metabolism in comparison to exercise only. A more profound effect was observed in case of anaerobic performance, thus it was concluded that even small doses of hGH stimulated additional protein synthesis following resistance exercise what allowed for significant increases in FFM, anaerobic power (W/kg) and capacity (J/kg) as evaluated obtained during the Wingate test. It was concluded that for a more significant effect of hGH therapy in regards to physical performance greater doses of this hormone have to be used, along with an intensive exercise program.

Endocrine Responses to Physical Training and Tribulus Terrestris Supplememtation in Middle-Age Men

84%

Wilk M., Michalczyk M., Chycki J., Czuba M., Roczniok R., Gołaś A., Zając A., Maszczyk A.

Central European Journal of Sport Sciences and Medicine

2016

vol. 13

issue 1

65-71

The aim of this study was to evaluate the effects of steroidal saponin supplementation on blood concentration of T, GH and IGF-1. The research involved 14 men between the age of 45 and 60 years. The duration of the experiment was 12 weeks. There were two series of laboratory tests. Independent tests were conducted at the beginning and after 12 weeks of the intervention. A two-way repeated measures ANOVA revealed a statistically significant effect of the intervention on the following variables: T-Ch (η2 = 0.542), HDL-Ch (η2 = 0.522), LDL-Ch (η2 = 0.587), T (η2 = 0.603), IGF-1 (η2 = 0.512) and GH (η2 = 0.621). Thus, FFM significantly increased while TBF and BM decreased in comparison to pre-intervention levels. The analyzed results indicate that treatment or supplementation of individual hormone deficiencies can be a successful form of counteracting the aging process. Nevertheless, the effects of TT supplementation on the concentration of T as well as GH and IGF-1, requires further studies, especially in middle-aged and older subjects, along with different exercise programs. The analyzed results indicate that treatment or supplementation of individual hormone deficiencies can be a major form of counteracting the aging process.

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1 Central European Journal of Sport Sciences and Medicine

1 Journal of Human Kinetics

1 2016

1 2010

2 Chycki J.

2 Czuba M.

1 Cholewa J.

1 Gołaś A.

1 Maszczyk A.

1 Michalczyk M.

1 Pilch J.

1 Poprzecki S.

1 Roczniok R.

1 Waśkiewicz Z.

1 Wilk M.

1 Zajâc A.

1 Zając A.

Search results

Effects of Growth Hormone Therapy and Physical Exercise on Anaerobic and Aerobic Power, Body Composition, Lipoprotein Profile in Middle Aged Men

Endocrine Responses to Physical Training and Tribulus Terrestris Supplememtation in Middle-Age Men