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1
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CHARACTERIZATION OF WATER STATE IN CHITOSAN HYDROGEL MEMBRANES

100%
Modrzejewska Z.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2011
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vol. 16
49 - 60
EN
In this study, the structure of hydrogel chitosan membranes was investigated. To determine the structure of hydrogel membranes the Differential Scanning Calorimetry (DSC) was used. On the basis of DSC spectra the enthalpy of the character of water in the structure were determined.
2
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SARS-COV-2 – THE LATEST GLOBAL THREAT AND THE PROSPECT OF COVID-19 THERAPY WITH THE USE OF CHITOSAN

64%
Pieklarz K., Modrzejewska Z.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2021
|
vol. 26
41-60
EN
Epidemics of infectious diseases have always been a threat to humanity and have contributed to increased mortality in the affected areas. This also applies to a new species of coronavirus identified in 2019, SARS-CoV-2, which is responsible for the COVID-19 pandemic. Despite preventive measures implemented all over the world to minimise the spread of the pathogen as well as the development of vaccines, which have been approved for emergency use, the situation is still worrying. Moreover, the problem is exacerbated by the lack of targeted treatments for COVID-19 patients. One possible solution is the using preparations based on natural raw materials, including chitosan. This biopolymer is of great interest due to a number of unique biological properties, among which its antiviral effect is a key feature. Hence, this paper presents the application possibilities of chitosan-based solutions in the prevention and treatment of viral diseases, with particular emphasis on COVID-19.
3
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MECHANISM OF FORMATION OF THERMOSENSITIVE CHITOSAN CHLORIDE GELS

51%
Modrzejewska Z., Skwarczyńska A., Maniukiewicz W., Douglas T. E. L.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2014
|
vol. 19
125+134
EN
The studies were carried out to develop the mechanism of chitosan gel formation in the presence of glycerol phosphate GP, taking into account suggestions presented in the literature. The analysis was carried out on the basis of a change in the gel structure after conditioning in water.
4
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PREPARATION AND CHARACTERIZATION OF A NEW GENERATION OF CHITOSAN HYDROGELS CONTAINING PYRIMIDINE RIBONUCLEOTIDES

51%
Pieklarz K., Tylman M., Modrzejewska Z.
Progress on Chemistry and Application of Chitin and its Derivatives
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2020
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vol. 25
192 - 200
EN
Damage to the nervous system, in particular spinal cord injuries, is a burden for the patient and is usually the cause of irreversible disability. The progress observed in the last decade in the fields of biology, biomaterial engineering and neurosurgery has created new treatment solutions while preventing further neurodegenerative processes. The most important research is focused on the implementation of polymer structures in clinical practice, especially chitosan hydrogels, which are the scaffolds for regenerating axons. This article presents a new generation of biomaterials that have the ability to gel in response to temperature changes; they are intended for injectable scaffolds for nerve cell cultures. Two types of hydrogels were prepared based on chitosan lactate and chitosan chloride using uridine 5’-monophosphate disodium salt. The structure of the systems was observed under a scanning electron microscope and examined using Fourier transform infrared spectroscopy. In addition, thermal properties were tested using differential scanning calorimetry.
5
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APPLICATIONS OF CHITOSAN–GRAPHENE OXIDE NANOCOMPOSITES IN MEDICAL SCIENCE: A REVIEW

51%
Pieklarz K., Tylman M., Modrzejewska Z.
|
|
vol. 23
5-24
EN
Combinations of biopolymers with nanostructured carbon materials have been the subject of interest of many scientists in recent years. Particularly significant are nanocomposites made of chitosan, which is a linear aminopolysaccharide obtained in the process of deacetylation of chitin, and graphene oxide (GO). These systems, due to the atypical properties of both components such as non-toxicity, biocompatibility with human tissues and organs as well as bacteriostaticity, are characterised by a wide range of biomedical applications. They may be used in emergency medicine as dressing materials which accelerate wound healing, as well as carriers of drugs/genes and biological macromolecules, for example proteins, peptides and nucleic acids. In addition, CS-GO systems can potentially be used in regenerative medicine as scaffolds for cell culture. For this reason, the current publication presents the possibilities of the application of chitosan–graphene oxide nanocomposites in medicine considering the characteristics of the system components.
6
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STRUCTURAL CHARACTERISTICS OF THERMOSENSITIVE CHITOSAN GLUTAMINATE HYDROGELS

51%
Modrzejewska Z., Nawrotek K., Zarzycki R., Douglas T.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2013
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vol. 18
|
issue 18
93-105
EN
Hydrogels that possess the ability of gelling in response to changes in the local environment, such as pH or temperature, have been examined extensively recently. In this paper the properties of thermosensitive chitosan hydrogels prepared with the use of chitosan glutaminate and -glycerophosphate are presented. The sol/gel transition point was determined based on the rheological properties. The structure of gels was observed under the Scanning Electron Microscopy (SEM) and was investigated by thermogravimetric (TG) and differential themogravimetric (DTG) analy¬sis and infrared (IR) spectroscopy. The crystallinity of gel structure was determined by X-ray Diffraction analysis (XRD).
7
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BIOLOGICAL PROPERTIES OF THERMOSENSITIVE CHITOSAN GELS CONDITIONING IN WATER

51%
Modrzejewska Z., Paluch D., Skwarczyńska A.
Progress on Chemistry and Application of Chitin and its Derivatives
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2015
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vol. 20
204-212
EN
In this paper the properties of thermosensitive chitosan hydrogels prepared with the use of chitosan salz (chloride and lactate) and -glycerophosphate are presented. Biological studies were carried out on thermogels without conditioning in water and on thermogels after 24 h conditioning in water. Experiments were conducted on a reference cell line L 929 (NCTC clone 929) American Type Culture Collection according to Annex C PN-EN ISO 10993-5
8
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STRUCTURAL RESEARCH OF THERMOSENSITIVE CHITOSAN-COLLAGEN GELS CONTAINING ALP

51%
Skwarczyńska A., Biniaś D., Modrzejewska Z.
Progress on Chemistry and Application of Chitin and its Derivatives
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2016
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vol. 21
176-186
EN
Introducing collagen, which is basic ingredient of bone tissue, into the structure of chitosan gels which are formed at the physiological body temperature, is aimed at creating the so-called biomimetic structures, i.e. close in their composition to the natural composition of bone tissue. Within the research the influence of collagen on structural properties of thermosensitive chitosan gels and the influence of ALP on structural properties of chitosan and chitosan-collagen gels was determined.
9
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SYNTHESIS OF SILVER NANOPARTICLES IN A CHITOSAN SOLUTION

51%
Modrzejewska Z., Zarzycki R., Sielski J.
Progress on Chemistry and Application of Chitin and its Derivatives
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2010
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vol. 15
63 - 72
EN
In the present study silver nanoparticles were obtained using the ability of chitosan to form chelate compounds with metal ions and taking advantage of its reducing properties. The reduction process was conducted at the temperature 60°C or applying γ radiation from 60Co cobalt source. A preliminary characteristic which allows us to realize the size of formed silver nanoparticles was made on the basis of the measurements of UV absorption and dynamic light dispersion.
10
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ADSORPTION OF SILVER IONS ON CHITOSAN HYDROGEL BEADS

51%
Sujka W., Rogacki G., Modrzejewska Z., Zarzycki R.
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EN
We investigated the adsorption of silver(I) from silver nitrate (AgNO3) and silver sulphate (Ag2SO4). We compared the adsorption ability of chitosan in the form of hydrogel beads with that of chitosan acetate – an initial solution from which the beads were derived. We developed a model of adsorption kinetics, assuming the simultaneous occurrence of the diffusion process and the chemical reaction. We confirmed and described the chemical nature of adsorption based on the Fourier-transform infrared and X-ray photoelectron spectra.
11
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THE INFLUENCE OF THE ADDITION OF COLLAGEN ON THE RHEOLOGICAL PROPERTIES OF CHITOSAN CHLORIDE SOLUTIONS

51%
Owczarz P., Rył A., Modrzejewska Z., Dziubiński M.
Progress on Chemistry and Application of Chitin and its Derivatives
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2017
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vol. 22
176 - 189
EN
Colloidal solutions of chitosan of crab origin with the addition of collagen obtained from cowhide were studied. Were presents the influence of collagen concentration and the method of preparing the sample on the obtained mechanical properties of the solutions and the observed phase transition temperature. Rheological measurements were performed to determine the viscoelastic properties and phase transition temperatures of these solutions. The study was conducted in the temperature range of 5–60°C with the use of classical techniques of rotational rheometry in the cone-plate measurement system. A significant influence of a collagen addition to chitosan chloride solutions on the viscoelastic properties of the systems was observed. The addition of collagen in all the cases increased the sol–gel phase transition temperature in comparison with the chitosan chloride solution containing β-glycerophosphate.
12
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STRUCTURAL AND BIOLOGICAL CHARACTERISTICS OF SELF-ORGANISING CHITOSAN HYDROGELS

45%
Pieklarz K., Tylman M., Modrzejewska Z., Galita G., Majsterek I.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2021
|
vol. 26
191-199
EN
Creating innovative methods of treatment and regeneration of damaged tissues or organs is a key challenge of the twenty-first century. The aim of this study was to determine the possibility of producing and characterising the properties of self-organising chitosan hydrogels prepared with the use of chitosan lactate/chloride and disodium hydrogen phosphate dodecahydrate as a cross-linking agent. The structure and supramolecular architecture of the biomaterials were evaluated by Fourier-transform infrared spectroscopy and polarised optical microscopy. Biological studies assessed cytotoxicity by contact with a human colon adenocarcinoma cell line. The colourimetric resazurin assay showed that the obtained chitosan hydrogels are non-cytotoxic materials. Thus, self-organising biomaterials hold great promise for application in tissue engineering.
13
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CYTOTOXICITY OF CHITOSAN BASED THERMO-SENSITIVE HYDROGELS INTENDED FOR NERVOUS TISSUE ENGINEERING

45%
Nawrotek K., Modrzejewska Z., Paluch D., Zarzycki R., Rusak A.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2015
|
vol. 20
222-235
EN
The damage to the central nervous system is one of the most difficult cases of trauma to treat. Over the last few years, increasing attention has been focused on the development of strategies based on biomaterials for regeneration and repair of the spinal cord injury. In particular, materials in the form of hydrogels based on chitosan are being actively investigated due to their intrinsic properties that are favorable in spinal cord tissue regeneration. The purpose of this study was to develop a thermo-gelling chitosan solution that will be prepared with the use of acids that naturally occur in the human nervous tissue. For this purpose, two types of chitosan gels were prepared based on chitosan glutamate and chitosan lactate. In order to reduce toxic action of the system obtained gels were conditioned in distilled water with pH 5.00. The changes in the structures of systems obtained were determined with the use of FTIR method. Biocompatibility was primarily evaluated through cytotoxicity testing by MTT assay with respect to mouse fibroblast cells.
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