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DETERMINATION OF THE HYDROLYTIC ACTIVITY OF WHOLE SALIVA USING CHITOSAN ASCORBATE AS A SUBSTRATE

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Kochańska B., Łukaszewska M., Ochocińska J.
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vol. 23
97 - 102
EN
The aim of this work was to evaluate of hydrolytic activity of whole saliva using chitosan ascorbate as a substrate. In this aim, the concentrations of N-acetyl-D-glucosamine were determined in saliva before addition of chitosan ascorbate, directly after addition and during incubation with chitosan ascorbate by 20 hrs. In this in vitro study were used sterile chitosan ascorbate in the form of powder. Chitosan was obtained from krill chitin. The ratio of ascorbic acid to chitosan was 1:1. The unstimulated whole saliva showed the hydrolytic activity in the presence of the chitosan ascorbate as a substrate.
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Określenie wartości diagnostycznej wybranych badań immunohistochemicznych u chorych na mięsaki macicy w aspekcie ich przydatności terapeutycznej i prognostycznej

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Jońska-Gmyrek J., Nasierowska-Guttmejer A., Bidziński M., Dańska-Bidzińska A.
Ginekologia Onkologiczna
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2007
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vol. 5
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issue 2
EN
Uterine sarcomas represent a rare and heterogenous group of tumours, sometimes demonstrating multidirectional differentiation. Histological type of the sarcoma influences the choice of therapeutic modality. Aim of paper: Determination of diagnostic value of selected immunohistochemical studies (MIB1, caldesmon, desmin, SMA, SrMa, CKAE1/3) in the definition of histological type of tumour. Assessment of expression of the protein c-kit (CD117) MIB1 and inhibin and their prognostic role. Material and method: Study material consisted of a group of patients with uterine sarcoma, treated at the Center of Oncology in Warsaw, Poland, since 1999 thru 2006, from whom surgical specimens and paraffin blocks were obtained. Of 120 eligible patients, complete clinical data and specimens suitable for foreseen studies were available in 66 cases and this group became the subject of further analyses. Immunohistochemical (IHC) tests were performed using a panel of antibodies (SMA, SrMa, desmin, h-caldesmon, CD10, CKAE, MIB1, inhibin and CD117). Diagnostic value of IHC studies was assessed by descriptive statistical tests. Original histopathological findings were confronted with the results of validated IHC tests. Survival was assessed based on Kaplan-Meier curves and follow-up time – by an inverse Kaplan-Meier curve. Prognostic factors were analysed by the Cox method. Threshold of statistical significance has been set at p=0.05. Results: Original microscopic findings have had to be modified as to histological type of sarcoma in about 1/3 of the cases. Histological diagnosis was an independent prognostic factor, influencing both overall survival rate and time to tumour recurrence. Prognostic factors influencing recurrence-free survival were: invasion of perivascular lymph space (lymph space invasion, LSI), proliferative index (MB1) and severity of tumour cell necrosis. Conclusions: Application of a panel of suitable IHC tests contributes to a more precise determination of tumour type, assisting in an optimal choice of adjuvant treatment modality and thus in improvement of the patients’ prognosis.
PL
Mięsaki macicy stanowią rzadko występującą, heterogenną grupę nowotworów, wykazującą niekiedy wielokierunkowe różnicowanie. Typ histopatologiczny mięsaka ma wpływ na wybór metody leczenia. Cel: Określenie przydatności diagnostycznej wybranych badań immunohistochemicznych (MIB1, kaldesmon, desmi-na, SMA, SrMa, CKAE1/3) w ocenie typu histopatologicznego. Ocena ekspresji białka c-kit (CD117), MIB1, oraz inhibiny w aspekcie przydatności prognostycznej. Materiał i metoda: Materiał badawczy stanowiła grupa chorych na mięsaki macicy leczonych w Centrum Onkologii - Instytucie im. Marii Skłodowskiej--Curie w Warszawie w latach 1999-2006, od których uzyskano preparaty i bloczki parafinowe. Spośród 120 chorych pełne dane kliniczne i preparaty nadające się do zastosowania badań uzyskano od 66 chorych, która to grupa stała się przedmiotem analizy. Wykonano badania immunohistochemiczne z użyciem panelu przeciwciał: SMA, SrMa, desmina, h-kaldesmon, CD10, CKAE, MIB1, inhibina oraz CD117. Do oceny wartości diagnostycznej badań immunohistochemicznych (IHC) zastosowano statystykę opisową. Zestawiono wynik pierwotnego badania histopatologicznego z wynikiem zweryfikowanym badaniami IHC. Do oceny przeżycia zastosowano krzywą Kaplana-Meiera, czas obserwacji mierzono odwrotną metodą Kaplana-Me-iera. Do analizy czynników predykcyjnych zastosowano metodę Coksa. Istotność statystyczną określono na poziomie p=0,05. Wyniki: W stosunku do rozpoznania pierwotnego typ histopatologiczny mięsaków został zmieniony w około 1/3 przypadków. Rozpoznanie histopatologiczne okazało się niezależnym czynnikiem rokowniczym mającym wpływ zarówno na przeżycie ogólne, jak i czas do nawrotu choroby. Czynnikami rokowniczymi w aspekcie przeżycia bez nawrotu choroby okazały się: zajęcie naczyniowej przestrzeni chłonnej (LSI), indeks proliferacyjny (MIB1), oraz stopień martwicy w komórkach guza. Wnioski: Zastosowanie panelu odpowiednich badań immunohistochemicznych ma wpływ na precyzyjne określenie charakteru guza, co niesie za sobą wybór odpowiedniej metody leczenia uzupełniającego, a tym samym, być może poprawę rokowania.
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The Menacing Misfit of the Dentition: A Case of Premolar Molarization

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Pauly G., Raphael B., Kashyap R. R., Kini R., Rao P. K., Bhandarkar G. P.
World News of Natural Sciences
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2019
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vol. 24
178-182
EN
Morphological variations can occur in human teeth. Developmental dental disorders occur either due to the abnormalities in the differentiation of the dental lamina and the tooth germs (anomalies in number, size and shape) or to abnormalities in the formation of the dental hard tissues (anomalies in structure). When such variations occur, they are more interesting to clinicians, anthropologists, and forensic dentists. Now, fusion and gemination aren’t an uncommon finding and affected mostly primary dentition and the permanent maxillary incisors. However, gemination of the posterior teeth is rare; permanent all the more than primary teeth. Gemination of a premolar is one such rare anomaly that arises when a single premolar tooth bud attempts to divide. Here, we present a case of gemination associated with the mandibular second premolar, showing a prodigious and unusual crown and root morphology.
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Treatment planning of complicated endodontic cases with the use of CBCT

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Tomaszewska I., Szupiany-Janeczek T., Pytko-Polończyk J.
Medicina Internacia Revuo
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2017
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vol. 28
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issue 108
182-188
EN
Cone beam computed tomography (CBCT) imaging is useful in various clinical situations including assessing dental morphology prior to endodontic treatment, locating tooth perforations, separated endodontic files, and resorptions. The aim of this paper was to present the usefulness of CBCT in endodontic treatment planning, through the review of two complicated endodontic cases. Two cases of failed endodontic treatment were presented in which CBCT allowed for correct diagnosis, as well as endodontic treatment qualification and planning. CBCT is especially useful when assessing endodontic treatment complications such as overextended root canal obturation material, separated endodontic instruments, and/or localization of perforations. Having the pros of CBCT in mind, one always has to weigh the added diagnostic value of CBCT with the economic cost of the tool employed, in order to make the best informed decision regarding accurate diagnosis and treatment.
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Prevalence of dental caries and oral hygiene habits in patients with Crohn’s disease living in urban and rural regions of southern Poland

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SZCZEKLIK K., OWCZAREK D., ŻAROW M., PYTKO-POLOŃCZYK J., MACH T.
Medicina Internacia Revuo
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2017
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vol. 28
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issue 109
280-287
EN
Patients with Crohn’s disease (CD) prefer carbohydrates and foods, which easy to digest, both risk factors of caries disease. The aim of this study was to evaluate the dental caries prevalence and oral hygiene habits in CD patients who live in urban and rural areas of the southern part of Poland in comparison to controls. Seventy one adult patients with CD and 61 age – and sex – matched volunteers were enrolled; 52% of patients were living in urban areas, 48% in rural regions. We studied: findings on clinical examination, calculation of BMI, blood hemoglobin and serum CRP levels, oral examination according to the WHO recommendations, with assessment of oral hygiene habits, dental history, visits to dentists. Presence of decayed (D), missing (M), filled teeth (F) were assessed, and the “Decayed, Missing, and Filled Teeth Index” (DMF-T) was calculated. Statistical methods included non-parametric tests and Spearman correlation coefficient estimation. Dental caries assessed by DMF-T index was higher in CD patients compared to controls. DMF-T was similar in patients from urban and rural areas (14.2±4.7 vs 15.4±2.1, respectively). M and F scores were comparable in both groups, but D score was higher in CD patients (p<0.01). No correlation was found between DMF-T index and place of living. Patients from rural areas less frequently used tooth brushing (68% vs 57%, p<0.05) and dental floss (11% vs 5%, p<0.05). Patients from urban areas visited dentists more frequently than those from rural regions. The prevalence of dental caries in the middle aged CD patients living in the southern region of Poland is higher in comparison to healthy controls. The prevalence of caries disease and oral hygiene habits in CD patients is comparable between patients living in urban areas and in rural regions.
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