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Ocena zgodności progów słyszenia w badaniach potencjałów słuchowych stanu ustalonego (ASSR), audiometrii tonalnej i słuchowych potencjałów wywołanych pnia mózgu (ABR) u młodych osób z prawidłowym słuchem

100%
Szymańska A., Gryczyński M., Pajor A.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
735-739
PL
Introduction. One of the basic audiological parameter in estimation of hearing sensitivity is hearing threshold. The need for an objective tool to effi ciently predict the audiogram caused that the use and importance of ASSR method is growing in recent times. However, the technique is quite new and needs to be still improved. Aim of the study was the estimation of behavioral audiogram in comparison with ABR and ASSR threshold of young adults with normal hearing. Material and methods. The study sample included 9 subjects with normal hearing (18 ears) with no abnormalities in otoscopy. Behavioral hearing thresholds and ASSRs to carrier frequencies of 0.5, 1, 2, and 4 kHz were obtained. The ASSRs were assessed with Bio-logic MASTER system by the use of four sinusoidal tones both frequency – and amplitude – modulated given simultaneously to every ear for each carrier frequency. The potentials are collected, averaged and analyzed in this method by the fast Fourier transform to yield statistically signifi cant responses. Electrophysiologic threshold responses for click ABR stimuli for the same carrier frequencies for right and left ear were obtained by the use of Bio-logic Navigator Pro unit. Differences and correlations between the ASSRs, ABRs and the behavioral thresholds were determined. Results. We discovered that the values of pure tone audiograms and ABRs thresholds values differ from ASSRs considerably. We could also observed that the difference between behavioral and ABRs threshold is less than for behavioral and ASSRs threshold. Conclusion. To conclude, this study shows that auditory steady-state responses technique is not useful method in estimating of hearing threshold of young adults with normal hearing.
2
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The estimation of behavioral audiograms, auditory brainstem response (ABR) thresholds and auditory steady-state response (ASSR) thresholds of young adults with normal hearing

100%
Szymańska A., Gryczyński M., Pajor A.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
735-739
EN
Introduction. One of the basic audiological parameter in estimation of hearing sensitivity is hearing threshold. The need for an objective tool to effi ciently predict the audiogram caused that the use and importance of ASSR method is growing in recent times. However, the technique is quite new and needs to be still improved. Aim of the study was the estimation of behavioral audiogram in comparison with ABR and ASSR threshold of young adults with normal hearing. Material and methods. The study sample included 9 subjects with normal hearing (18 ears) with no abnormalities in otoscopy. Behavioral hearing thresholds and ASSRs to carrier frequencies of 0.5, 1, 2, and 4 kHz were obtained. The ASSRs were assessed with Bio-logic MASTER system by the use of four sinusoidal tones both frequency – and amplitude – modulated given simultaneously to every ear for each carrier frequency. The potentials are collected, averaged and analyzed in this method by the fast Fourier transform to yield statistically signifi cant responses. Electrophysiologic threshold responses for click ABR stimuli for the same carrier frequencies for right and left ear were obtained by the use of Bio-logic Navigator Pro unit. Differences and correlations between the ASSRs, ABRs and the behavioral thresholds were determined. Results. We discovered that the values of pure tone audiograms and ABRs thresholds values differ from ASSRs considerably. We could also observed that the difference between behavioral and ABRs threshold is less than for behavioral and ASSRs threshold. Conclusion. To conclude, this study shows that auditory steady-state responses technique is not useful method in estimating of hearing threshold of young adults with normal hearing.
3
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Ocena fenotypowa pacjentów z zespołem Pendreda

76%
Maciaszczyk K., Pniewska-Siark B., Gajewicz W., Stefańczyk L., Durko T., Pajor A., Lewiński A.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
740-746
PL
Introduction. The Pendred syndrome (PS) is an autosomally recessively inherited disease. Its diagnosis requires identifi cation of the classical triad of symptoms, including hypoacusis, thyroid goitre and iodine organifi cation defect in the thyroid, which may lead to thyroid functional disorders of hypothyroidism. SP is accompanied by anatomical anomalies. The objective is the hearing and balance system evaluation and the analysis of the inner ear structure and also the assessment of the function and structure of thyroid gland. Material and methods. For the research four families were qualifi ed, 7 persons with PS, 12 persons altogether. In all the patients the anamnesis in the form of a questionnaire and laryngological examination were performed. It was followed by pure tone, speech and impedance audiometry and brainstem response testing as well. ENG was also conducted. Patients with hearing loss were subjected to magnetic resonance of temporal bone. For the whole group thyroid hormones levels and iodine organifi cation in the thyroid identifi ed in a test with potassium perchlorate were measured and also USG and scyntography were conducted. Results. In audiological examination in 3 cases deafness, in 2 cases profound hypoacusis and in 2 mild hypoacusis were recognised. In the group in 2 patients the hypoacusis was of a mixed type. In radiological assessment the labirynth showed anatomical anomalies in the form of enlargement of the vestibular aqueduct and the endolyphatic sac, yet in 3 patients the anomalies also concerned the structure of cochlear and semicircular canals. Endocrine examination showed hypothyroidism in 5, its subclinical form in 1, diffuse thyroid goitre in 4 and nodular thyroid goiter in 2 cases. Conclusions. A complex clinical evaluation: endocrine and audiological, together with radiological diagnostic imaging, supported by molecular studies of SLC26A4 gene, are the procedures, necessary for complete and accurate diagnosis of PS and EVAS.
4
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Phenotypic evaluation of patients with Pendred syndrome

76%
Maciaszczyk K., Pniewska-Siark B., Gajewicz W., Stefańczyk L., Durko T., Pajor A., Lewiński A.
Otolaryngologia Polska
|
2008
|
vol. 62(6)
740-746
EN
Introduction. The Pendred syndrome (PS) is an autosomally recessively inherited disease. Its diagnosis requires identifi cation of the classical triad of symptoms, including hypoacusis, thyroid goitre and iodine organifi cation defect in the thyroid, which may lead to thyroid functional disorders of hypothyroidism. SP is accompanied by anatomical anomalies. The objective is the hearing and balance system evaluation and the analysis of the inner ear structure and also the assessment of the function and structure of thyroid gland. Material and methods. For the research four families were qualifi ed, 7 persons with PS, 12 persons altogether. In all the patients the anamnesis in the form of a questionnaire and laryngological examination were performed. It was followed by pure tone, speech and impedance audiometry and brainstem response testing as well. ENG was also conducted. Patients with hearing loss were subjected to magnetic resonance of temporal bone. For the whole group thyroid hormones levels and iodine organifi cation in the thyroid identifi ed in a test with potassium perchlorate were measured and also USG and scyntography were conducted. Results. In audiological examination in 3 cases deafness, in 2 cases profound hypoacusis and in 2 mild hypoacusis were recognised. In the group in 2 patients the hypoacusis was of a mixed type. In radiological assessment the labirynth showed anatomical anomalies in the form of enlargement of the vestibular aqueduct and the endolyphatic sac, yet in 3 patients the anomalies also concerned the structure of cochlear and semicircular canals. Endocrine examination showed hypothyroidism in 5, its subclinical form in 1, diffuse thyroid goitre in 4 and nodular thyroid goiter in 2 cases. Conclusions. A complex clinical evaluation: endocrine and audiological, together with radiological diagnostic imaging, supported by molecular studies of SLC26A4 gene, are the procedures, necessary for complete and accurate diagnosis of PS and EVAS.
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