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Preferentially Oriented Growth of L1₀ FePt on Si Substrate

100%
Kaushik N., Sharma P., Tanaka S., Makino A., Esashi M.
Acta Physica Polonica A
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2015
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vol. 127
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issue 2
611-613
EN
Tilting the magnetic easy axis of L1₀ FePt and/or introducing a magnetic buffer layer is most effective in realizing the L1₀ based magnetic recording media. Here we report on preferentially oriented growth of L1₀ FePt with tilted magnetic easy axis. FePt films of thickness up to 170 nm were deposited on Si substrate with a soft magnetic underlayer of glassy FeSiB, FeSiBP and CoFeTaB. Effects of processing conditions on the structural and magnetic properties were studied. A polycrystalline growth of FePt (i.e. mixed orientation) was observed with the underlayer of FeSiB and FeSiBP, but CoFeTaB promotes preferentially oriented growth along (111) crystallographic direction. Compared to FePt films grown on Si substrate, coercivity (H_{c}) reduces significantly with the introduction of soft magnetic underlayer. The magnetic easy axis of (111) L1₀ FePt is tilted 36 out of plane and it is very promising for tilted magnetic recording media.
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The effects of organic solvents on poly(ADP-ribose) polymerase-1 activity: implications for neurotoxicity

86%
Banasik M., Stedeford T., Strosznajder R. P., Persad A. S., Tanaka S., Ueda K.
Acta Neurobiologiae Experimentalis
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2004
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vol. 64
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issue 4
467-473
EN
Poly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30), also termed as poly(ADP-ribose) synthetase, is a key enzyme in the recognition and repair of damaged DNA. Several conditions (e.g., ischemia-reperfusion or chemical-induced injury) have been shown to overactivate PARP-1, causing neurodegeneration and necrotic or apoptotic cell death from NAD+ and ATP depletion. In contrast, inhibitors of PARP-1 have been shown to have a neuroprotective effect by ameliorating this response. The purpose of this study was to determine the effects of three routinely used organic solvents (ethanol, methanol, and dimethyl sulfoxide (DMSO)) on the activity of purified PARP-1. A dose-response was examined with each of these solvents. A 112% and 82% increase in PARP-1 activity was observed with 15% ethanol and 20% methanol, respectively. In contrast, a near 20% decrease in the activity was observed with 4% DMSO. Kinetic analysis revealed that the maximal velocity remained unchanged with increasing concentrations of DMSO up to 20%, indicating that DMSO is a competitive inhibitor of PARP-1. Thus, PARP-1 inhibition by DMSO depends on NAD+ concentration and in some pathological processes might be significant even at low DMSO concentrations. Our findings suggest that the interpretation of data from dose-response studies obtained when using common organic solvents may be dramatically skewed, either exaggerating the inherent toxicity of the compound or masking its potential for damage.
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