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Analysis of advanced additive technology in direct metal laser sintering and precision casting method

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Robl J., Sedlák J., Pokorný Z., Ňuksa P., Barényi I., Majerík J.

Bulletin of the Polish Academy of Sciences: Technical Sciences

2020

issue 1

Physico-Chemical and Biological Properties of Arsenic Sulfide (As_{55}S_{45}) Nanosuspension Prepared by Milling

100%

Bujňáková Z., Shpotyuk O., Sedlák J., Pastorek M., Turianicová E., Baláž P., Ingram A.

Acta Physica Polonica A

2014

vol. 126

issue 4

902-906

Nanosuspension based on melt-quenched arsenic sulfide of nominal As_{55}S_{45} composition was prepared by nanomilling and tested as potential anticancer drug. Polyvinylpyrrolidone was used as steric stabilizer and inhibitor of agglomeration. Individual nanoparticles had average size of 192 nm (determined by photon cross-correlation spectroscopy) and had several times better dissolution ability in comparison with bulk As_{55}S_{45}. Effect of nanomilling is shown to be associated with formation of arsenic sulfide crystalline nanoparticles and free-volume entities located at the interface between nanoparticles and surrounding matrix as it follows from positron annihilation measurements. Cytotoxicity tests were performed using human melanoma cell line Bowes and confirmed high toxicity of the studied nanosuspension.

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1 Acta Physica Polonica A

1 Bulletin of the Polish Academy of Sciences: Technical Sciences

1 2020

1 2014

2 Sedlák J.

1 Baláž P.

1 Barényi I.

1 Bujňáková Z.

1 Ingram A.

1 Majerík J.

1 Pastorek M.

1 Pokorný Z.

1 Robl J.

1 Shpotyuk O.

1 Turianicová E.

1 Ňuksa P.

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Analysis of advanced additive technology in direct metal laser sintering and precision casting method

Physico-Chemical and Biological Properties of Arsenic Sulfide (As_{55}S_{45}) Nanosuspension Prepared by Milling