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TGF-β1, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers

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Marek A., Zagierski M., Liberek A., Aleksandrowicz E., Korzon M., Krzykowski G., Kamińska B., Szlagatys-Sidorkiewicz A.

issue 3

411-414

Objective: To determine transforming growth factor (TGF) β1, interleukin (IL) 4, and IL-10 concentrations in human milk and to assess the relationship between allergic disorders in mothers and the content of the interleukins in their milk. Material and methods: Thirty allergic and 46 healthy mothers were included in the study. Colostrum was collected 2-3 days after delivery. Cytokine concentrations were determined with commercial enzyme-linked immunosorbent systems. Results: TGF-β1was found in milk from 23 women in the control group (53.49%) and 11 in the allergy group (37.93%). When TGF-β1 was present, the median concentration was higher in the allergy group than in the control (61.5 and 30.4 pg/mL, respectively; P < 0.004). IL-10 was present in the colostrum of all the women and the median IL-10 concentration did not differ between the allergy (50.5 pg/mL) and control (51.5 pg/mL) groups. The probability of occurrence of a positive IL-4 value in the allergy group was greater than in the control group (chi-squared [df=1] = 2.60, P < 0.053). Median IL-4 level did not differ significantly between the two groups (0.5 and 0.5 pg/mL respectively). Conclusions: TGF-β1 was detected less often in the colostrum of allergic mothers than in that of mothers without allergy (but the difference was not statistically significant). IL-4 was found more often in the colostrum of allergic mothers than nonallergic ones. The allergy status did not correlate with IL-10 concentration.

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1 Acta Biochimica Polonica

1 2009

1 Aleksandrowicz E.

1 Kamińska B.

1 Korzon M.

1 Krzykowski G.

1 Liberek A.

1 Marek A.

1 Szlagatys-Sidorkiewicz A.

1 Zagierski M.

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TGF-β1, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers