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Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells

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Józkowicz A., Pankiewicz J., Dulak J., Partyka Ł., Wybrańska I., Huk I., Dembińska-Kieć A.

Acta Biochimica Polonica

1999

vol. 46

issue 3

703-715

Modulation of the human preadipocyte mitochondrial activity by beta-carotene

100%

Śliwa A., Góralska J., Czech U., Gruca A., Polus A., Zapała B., Dembińska-Kieć A.

2012

vol. 59

issue 1

39-41

Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria.

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2 Acta Biochimica Polonica

1 2012

1 1999

2 Dembińska-Kieć A.

1 Czech U.

1 Dulak J.

1 Gruca A.

1 Góralska J.

1 Huk I.

1 Józkowicz A.

1 Pankiewicz J.

1 Partyka Ł.

1 Polus A.

1 Wybrańska I.

1 Zapała B.

1 Śliwa A.

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Nitric oxide mediates the mitogenic effects of insulin and vascular endothelial growth factor but not of leptin in endothelial cells

Modulation of the human preadipocyte mitochondrial activity by beta-carotene