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Elimination of Magnetic Nanoparticles with Various Surface Modifications from the Bloodstream in vivo

100%

Tomasovicova N., Khmara I., Koneracka M., Zavisova V., Kubovcikova M., Antal I., Kovac J., Muckova M., Kopcansky P.

Acta Physica Polonica A

2017

vol. 131

issue 4

1159-1161

The magnetic nanoparticles with the core diameter 10 nm stabilized by sodium oleate and bovine serum albumin in phosphate buffer have been modified by different biocompatible substances such as poly(ethylene glycol) (PEG), dextran (DEX), and polyvinylpyrrolidone (PVP). Prepared biocompatible magnetic fluids were characterized to obtain the particle size distribution using scanning electron microscopy and the dynamic light scattering method. To study the elimination of different modified magnetic nanoparticles from bloodstream, the biocompatible samples were applied intravenously to the mice bloodstream with further blood specimens collecting in given time intervals. Magnetic moment of the lyophilized blood samples was measured by SQUID magnetometer. Time dependence of magnetic moment of magnetic nanoparticles and magnetic nanoparticles modified by DEX, PEG and PVP normalized to the Fe₃O₄ showed that the circulation time of magnetic nanoparticles in the bloodstream depends on the substance used for modification. The unmodified magnetic nanoparticles were trapped by reticuloendothelial system within 1 h while magnetic nanoparticles modified by DEX, PEG and PVP circulated in blood up to 3 h.

Presence of Magnetic Fluids Leads to the Inhibition of Insulin Amyloid Aggregation

81%

Gazova Z., Siposova K., Koneracka M., Antosova A., Zavisova V., Kubovcikova M., Fedunova D., Bagelova J., Tomasovicova N., Daxnerova Z., Kopcansky P.

Acta Physica Polonica A

2012

vol. 121

issue 5-6

1305-1307

Insulin amyloid aggregation caused serious problems in the treatment of diabetes by insulin injection or by insulin pumps. In vitro formation of insulin amyloid fibrils was investigated in presence of several types of magnetic fluids. Interaction of magnetic fluids with insulin amyloid aggregates led to decrease of insulin fibrillization. The inhibiting activities are affected by coating layer of studied magnetic fluids as well as by their physical properties (diameter, concentration of magnetic particles). The highest inhibiting efficiencies were detected for sterically stabilized magnetic fluids in saline solution (75%) and for magnetic fluids modified by dextran (80%).

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2 Acta Physica Polonica A

1 2017

1 2012

2 Koneracka M.

2 Kopcansky P.

2 Kubovcikova M.

2 Tomasovicova N.

2 Zavisova V.

1 Antal I.

1 Antosova A.

1 Bagelova J.

1 Daxnerova Z.

1 Fedunova D.

1 Gazova Z.

1 Khmara I.

1 Kovac J.

1 Muckova M.

1 Siposova K.

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Elimination of Magnetic Nanoparticles with Various Surface Modifications from the Bloodstream in vivo

Presence of Magnetic Fluids Leads to the Inhibition of Insulin Amyloid Aggregation