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The use of platelet-rich plasma in anti-aging therapy (overview)

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Chorążewska M., Piech P., Pietrak J., Kozioł M., Obierzyński P., Maślanko M., Wilczyńska K., Tulwin T., Łuczyk R., Zukow W., ojs o., Muszkieta R., Gozhenko E. A., adm a., Gozhenko A., Badiuk N. S., Zukow W., Szulc A., Gozhenko A. I., Gozhenko A. I., Gozhenko A. I., Badiuk N. S., Gotowski R., ojs o., Zukow W., adm a., Muszkieta R., Zukow W., Badiuk N. S., Gozhenko A., Gozhenko E. A., Gozhenko A. I., Gozhenko A. I., Gozhenko A. I., Badiuk N. S., Szulc A., Gotowski R.
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vol. 7
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issue 11
EN
IntroductionAging stands for the changes in the human body, which are recognized as natural processes that concern every person and are related to the passage of time. Despite ‘normalness’ of the process, a tendency is emerging to treat aging as a pathology requiring proper diagnostics. Consequently, an ‘anti-aging’ medicine has been established - defined as study of preventing and slowing down the process of aging.Aim of the studyThe aim of this study is to summarize and present the current knowledge, based on the overview of writing on the properties and effectiveness of the use of PRP in anti-aging therapy.  Description of knowledge Autologous platelet-rich plasma is a concentrate of human blood platelets suspended in a small amount of plasma, wherein concentration of thrombocytes is higher than initial concentration. For autologous plasma to have high healing properties, platelet levels should be at least 1 million in 5 ml of plasma.The basic condition for initiating repair and regenerative processes in vivo is the formation of a blood clot. Also, by degranulating, platelets release many growth factors, such as PDGF, TGF-β, EGF, FGF, VEGF and others, which are involved not only in blood coagulation, but also in immune response and tissue healing.The large variety of PRP-obtaining methods and the range of concentration levels of growth factors in PRP may lead to ambiguity in the literature, as to the extent to which formulation was actually used in a variety of preclinical and clinical studies. Some of those studies are presented in this article. Summary Platelet-rich treatments are part of the growing popularity of regenerative medicine, which is beginning to be recognized as the medicine of the future. However, without proper control methods or optimization of numerous variables (e.g. concentration or ratio of growth factors) during PRP preparation, it is not known which ingredients are needed and preferred, and which are harmful for tissue regeneration.However, numerous studies show PRP injection as a promising method of rejuvenating the skin, therefore platelet-rich treatments are an important part of the growing popularity of regenerative medicine.
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Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs

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Dyndor K., Dworzanski W., Pliszczynska-Steuden M., Cendrowska-Pinkosz M., Chroscicki T., Dyndor P., Dworzanska A., Piasek E., Piech P., Ruchala M., Golec K., Hermanowicz-Dryka T.
Current Issues in Pharmacy and Medical Sciences
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2015
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vol. 28
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issue 3
200-203
EN
Non-selective cyclooxygenase (COX) inhibitors, commonly referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are among the most taken pharmaceuticals. In adults, they can have a series of side effects, including especially gastroenterotoxicity, hepatotoxicity, nephrotoxicity, chondrotoxicity, and neurotoxicity, and they can induce allergic reactions. Any exacerbation of symptoms depends on the chemical structure of the drug, its dosage and duration of exposure, individual sensitivity, comorbidities and the degree of inhibition of basic COX isoenzymes - the constitutive (COX-2) and induced (COX-1) expressions. However, data on prenatal toxicity are inconsistent. Classic nonselective COX inhibitors do not result in an increase in the risk of developing significant congenital defects; however, if used in the late-pregnancy period, they can have an adverse effect on the foetus, by inducing the premature closure of the ductus arteriosus and by producing a tocolytic effect. Individual reports also indicate the increased risk of developing heart and anterior abdominal wall defects, as well as hypospadias.
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