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1

Biohybrid artificial organs in therapy of systemic disorders

100%
Jankowski T.
Biotechnologia
|
1999
|
issue 1
45-58
EN
Transplantation of cells and tissues secreting a desirable therapeutic product shows a potential in the treatment of many human diseases such as diabetes, hemophilia, dwarfism, immunodeficiencies, anemia, hypocalcemia, and some neurodegenerative disorders. To avoid graft rejection, the transplanted tissue is immunoisolated in a semipermeable membrane, thereby creating an implantable biohybrid artificial organ. A number of encapsulation systems such as vascular implants, diffusion chambers, and microcapsules have been developed for cell therapy. The encapsulation membrane should allow for diffusion of nutrients, dissolved gases, and wastes and should be impermeable to the components of the immune system, including cellular and humoral components. Encapsulation cell technology offers a solution to the problem of donor organ supply, not only by potentially allowing the transplantation of cells and tissues without immunosuppresion, but also by permitting use of tissue isolated from animals. However, further research is required in the areas of encapsulation device design and tissue supply from primary or cell-culture sources.
2

The separation of biotechnology products in aqueous two-phase systems. Part I ? Theoretical background

63%
Zielinska-Dawidziak M., Jankowski T.
Biotechnologia
|
2002
|
issue 1
142-152
EN
The article presents the principles of liquid-liquid extraction in aqueous two-phase systems which offer a great potential for the recovery and purification of various biomolecules, cells and organelles from fermentation slurries. These systems consisting of a solution of two polymers (e.g. polyethylene glycol/dextran), polymer and salt (e.g. polyethylene glycol/phosphate) or a thermoseparating polymer (oxyethylene-oxypropylene copolymer) offer mild separation conditions due to the high concentration of water, which makes them suitable for biotechnology applications.
3

Adjustments for heterogeneous herd-year variances in a random regression model for genetic evaluations of Polish Black-and-White cattle

51%
Strabel T., Jankowski T., Jamrozik J.
Journal of Applied Genetics
|
2006
|
vol. 47
|
issue 2
125-130
EN
The study investigated the existence of heterogeneous variance in first-lactation daily milk yield of Polish Black-and-White cows across herds in different years. Bayesian Information Criterion was used to show that the model with unequal residual variances for different herd-years was more plausible than the model assuming equal variances. A method of adjusting phenotypic records was developed to account for unequal variability in herd-years. Factors used for the data adjustment considered variation of general residuals and residuals for specific herd-years. The size of herd-year was also taken into account. Varied power of corrections was used to analyze the effect of adjustment on estimated breeding values. The method was applied to daily milk records of 817 165 primiparous cows. The effectiveness of the data adjustment was evaluated by the analysis of differences between each bull's breeding value and its parental index. Data correction reduced the average difference and variance of differences between breeding values and parental indices. Accounting for the size of herd-year classes in correction factors improved the efficiency of heterogeneous variance adjustment.
4

The separation of biotechnology products in aqueous two-phase systems. Part II ? Applications

51%
Zielinska-Dawidziak M., Jankowski T., Zieli?ska-Dawidziak M.
Biotechnologia
|
2002
|
issue 2
102-112
EN
This paper is focused on actual and potential applications of aqueous two-phase systems in the separation of biotechnology products. Applications of bioconversions, purification of enzymes and other biomolecules in these systems, proposed schemes of separation, and advantages and disadvantages are presented. The experimental and industrial results indicate high efficiency of the separations of biological materials in aqueous two-phase systems, which may result in the development of new technologies.
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