RNA interference and its therapeutic potential

• Authors: Anubrata Ghosal , Ahmad Kabir , Abul Mandal
• Languages of publication: EN

Abstracts

EN

RNA interference is a technique that has become popular in the past few years. This is a biological method to detect the activity of a specific gene within a cell. RNAi is the introduction of homologous double stranded RNA to specifically target a gene’s product resulting in null or hypomorphic phenotypes. This technique involves the degradation of specific mRNA by using small interfering RNA. Both microRNA (miRNA) and small interfering RNA (siRNA) are directly related to RNA interference. RNAi mechanism is being explored as a new technique for suppressing gene expression. It is an important issue in the treatment of various diseases. This review considers different aspects of RNAi technique including its history of discovery, molecular mechanism, gene expression study, advantages of this technique against previously used techniques, barrier associated with this technique, and its therapeutic application.

Keywords

EN

Cancer; MicroRNA; Interfering RNA; Disease

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2011
• Volume: 6
• Issue: 2
• Pages: 137-147

Dates

published

1 - 4 - 2011

online

17 - 2 - 2011

Contributors

author

Anubrata Ghosal

• Institute of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, 2200, Denmark

author

Ahmad Kabir

• School of Biological Sciences, Flinders University, Flinders, SA, 5042, Australia

author

Abul Mandal

• System Biology Research Center, School of Life Sciences, University of Skövde, Box 408, SE-541 28, Skövde, Sweden

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Identifiers

DOI

10.2478/s11536-011-0005-5