Intercellular adhesion molecule-1 gene polymorphisms in patients with familial mediterranean fever

• Authors: Senol Kobak , Arzu Celebi , Fahrettin Oksel , Yasemin Kabasakal , Ulus Akarca
• Languages of publication: EN

Abstracts

EN

Familial Mediterranean fever (FMF) is a disease of unknown etiology characterized by recurrent attacks of polyserositis and fever. Intercellular adhesion molecule-1 (ICAM-1) is known to contribute inflammatory conditions by regulating leukocyte localization at inflammatory sites. The aim of this study was to evaluate the probable association of ICAM-1 G/R 241 and ICAM-1 E/K 469 polymorphisms according to susceptibility with FMF. Sixty-seven FMF patients and 83 healthy volunteers were included in the study. Genomic DNA was extracted from EDTA-preserved whole blood of whole series of patients and controls, and genotyped by polymerase chain reaction (PCR) and allele-specific oligonucleotide techniques for ICAM-1 polymorphisms G/R at codon 241 and E/K at codon 469. The ICAM-1 241 genotype and allele frequencies of FMF patients and healthy volunteers were similar. The frequency of ICAM-1 K469 homozygosity was significantly lower in FMF patients than in the controls (32.8% vs 50.7% subsequently, p=0.03). Moreover, ICAM-1 E469 allele was more frequent in FMF patients than in controls (44.8% vs 32.3%, p:0.03). Our results showed that ICAM-1 469 gene polymorphism could contribute to the pathogenesis of FMF.

Keywords

EN

Familial Mediterranean fever; Intercellular adhesion molecule; Genetic polymorphism

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 6
• Pages: 679-682

Dates

published

1 - 12 - 2010

online

7 - 10 - 2010

Contributors

author

Senol Kobak

• Department of Rheumatology, Manisa Hospital, 45020, Manisa, Turkey

author

Arzu Celebi

• Department of Gastroenterology and Hepatology, Ege University School of Medicine, 45020, Manisa, Turkey

author

Fahrettin Oksel

• Department of Rheumatology, Ege University School of Medicine, 45020, Manisa, Turkey

author

Yasemin Kabasakal

• Department of Rheumatology, Ege University School of Medicine, 45020, Manisa, Turkey

author

Ulus Akarca

• Department of Gastroenterology and Hepatology, Ege University School of Medicine, 45020, Manisa, Turkey

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Identifiers

DOI

10.2478/s11536-010-0037-2