The effects of parenteral glutamine on intestinal adaptation in a rat model of short bowel syndrome

• Authors: Ahmet Ucar , Hilal Kocdor , Aras Canda , Sadiye Unlu , Ruksan Cehreli , Mehmet Kocdor
• Languages of publication: EN

Abstracts

EN

Short bowel syndrome (SBS) is characterized by the malabsorption of nutrients and fluids that occurs after major intestinal resection, resulting from an adaptation process that begins immediately to increase the mucosal surface area and absorption. Certain nutrients and trophic factors are widely used to increase intestinal adaptation following massive intestinal resection. The efficacy and benefits of glutamine on the intestinal adaptation process is still controversial. This study was conducted to determine the effects of parenteral glutamine administration on intestinal adaptation in a rat model of SBS. Fourteen male Wistar rats were divided into two groups; all 14 underwent 75% small bowel resection. Within each group, rats were assigned to 14 days of treatment with subcutaneous glutamine (0.3 g/kg/day) or isotonic saline daily. Weight changes and histological intestinal adaptation parameters (mucosal thickness, villus height, and crypt depth) were measured. Non-mucosal intestinal changes were evaluated by intestinal fractioned collagen analysis. All rats initially lost weight and began to gain weight postoperatively; however, they did not reach their preoperative weights during the experiment and there was no significant difference between the groups. Histological adaptation parameters were significantly increased after 75% intestinal resection in both groups compared to paired native samples (P<0.01); although the percent of increase was slightly higher in Gln group, no significant difference was detected between the two groups. Fractioned-collagen amounts were found to be similar between groups. The results indicated that parenteral glutamine administration alone does not improve the intestinal adaptation process after massive intestinal resection in rats.

Keywords

EN

Short bowel syndrome; Glutamine; Intestinal adaptation; Collagen; Malabsorption

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2010
• Volume: 5
• Issue: 1
• Pages: 115-122

Dates

published

1 - 2 - 2010

online

29 - 1 - 2010

Contributors

author

Ahmet Ucar

• Departments of Surgery, School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

author

Hilal Kocdor

• Basic Oncology, Institute of Oncology, Dokuz Eylul University, 35340, Izmir, Turkey

author

Aras Canda

• Departments of Surgery, School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

author

Sadiye Unlu

• Pathology School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

author

Ruksan Cehreli

• Preventive Oncology, Institute of Oncology4, Dokuz Eylul University, 35340, Izmir, Turkey

author

Mehmet Kocdor

• Departments of Surgery, School of Medicine, Dokuz Eylul University, 35340, Izmir, Turkey

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Identifiers

DOI

10.2478/s11536-008-0062-6