Chronic pain in urological diseases: a clinical review

• Authors: Domenico Prezioso , Raffaele Galasso , Gennaro Iapicca , Emanuele Annunziata , Mario Martino , Fabrizio Iacono
• Languages of publication: EN

Abstracts

EN

Chronic pain is the central problem in a variety of urological diseases. Pain is an unpleasant sensory and emotional experience associated with either actual or potential tissue damage, or described in terms of such damage. The aim of this research was to update knowledge about the ultrastructural, clinical, psychological and therapeutic aspects of chronic pain in urological diseases, in particular in chronic pelvic syndrome. In this paper we have revisited the most significant and discussed articles published in the last twenty five years, with particular references on the 2008 European Guidelines, searching key words (chronic pelvic pain syndrome, chronic pelvic pain, chronic prostatitis, interstitial cystitis, prostatodynia, urological disease) and data with a high level of evidence. The articles that we have analyzed show that pain is characterized by an initial tissue injury that can lead to sensitization, which is a decrease in the intensity of the stimulus needed to elicit a response by the nerve, involving the peripheral and central nervous systems. The chronic pain state is characterized by loss of inhibitory interneurons, establishment of aberrant excitatory synaptic connections and long-term potentiation of response due to changes in sensitivity of nerve synapses. Stress and hormones might also play a role in central sensitization. Pain also has a cognitive and emotional component. It is very difficult to treat, given the complex nature of the response and the interaction of physiological aspects

Keywords

EN

Chronic pelvic pain syndrome; Chronic pelvic pain; Chronic prostatitis; Interstitial cystitis; Prostatodynia

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2008
• Volume: 3
• Issue: 4
• Pages: 381-389

Dates

published

1 - 12 - 2008

online

22 - 10 - 2008

Contributors

author

Domenico Prezioso

• Department of Urology, University “Federico II” of Naples, 80131, Naples, Italy

author

Raffaele Galasso

• Department of Urology, University “Federico II” of Naples, 80131, Naples, Italy

author

Gennaro Iapicca

• Department of Urology, University “Federico II” of Naples, 80131, Naples, Italy

author

Emanuele Annunziata

• Department of Urology, University “Federico II” of Naples, 80131, Naples, Italy

author

Mario Martino

• Department of Urology, University “Federico II” of Naples, 80131, Naples, Italy

author

Fabrizio Iacono

• Department of Urology, University “Federico II” of Naples, 80131, Naples, Italy

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Identifiers

DOI

10.2478/s11536-008-0066-2