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Journal

2013 | 11 | 12 | 2040-2047

Article title

UV-absorption studies of interaction of karanjin and karanjachromene with ds. DNA: Evaluation of binding and antioxidant activity

Content

Title variants

Languages of publication

EN

Abstracts

EN
Two flavonoids, karanjin (Kj) and karanjachromene (Kc) have been investigated spectrophotometrically for their mode of interactions with double stranded (ds)-DNA at blood (7.4) and stomach (4.7) pH and at human body temperature (37°C). Benesi-Hildebrand equation was used to evaluate the binding constants, K b . Binding constants at both pH values and at body temperature showed stronger binding of both the flavonoids and formation of 1:1 flavonoid-DNA complex via intercalative mode. However, K b values for karanjin were evaluated to be comparatively greater than karanjachromene at both pH values. The highest value of binding constant (1.32×105 M−1) for karanjin at blood pH (7.4) demonstrated its comparatively stronger binding and greater effectiveness at this pH. Standard Gibbs free energy changes (ΔG) of flavonoid-DNA complexes were calculated as negative values and indicative of spontaneity of their binding. Both flavonoids showed significant DNA protection activity. [...]

Publisher

Journal

Year

Volume

11

Issue

12

Pages

2040-2047

Physical description

Dates

published
1 - 12 - 2013
online
26 - 9 - 2013

Contributors

author
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
author
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
  • Department of Chemistry, Allama Iqbal Open University, Islamabad, 44000, Pakistan
  • Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
author
  • Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-013-0327-z
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