Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results

Journal

2009 | 7 | 3 | 337-342

Article title

Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a] pyrimidines and their antimicrobial activities

Content

Title variants

Languages of publication

EN

Abstracts

EN
Comparative studies were performed on a series of 2,4-di and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines, which were synthesized with conventional and microwave heating methods. In microwave irradiation method, approximately, 95–97.5% of the reaction time was increased and 1–45% yield increase was obtained. All compounds were able to inhibit the growth of the screened microorganisms in vitro with MIC values between 3.9–250 μg mL−1. The highest activity was expressed by compound IIId (2,4-diphenyl-benzo[4,5]imidazo[1,2-a] pyrimidine), which has the MIC value of 3.9 μg mL−1 and 31.2 μg mL-1 for Penicillium natatum ATCC 24791 and E. faecalis ATCC 29212, respectively. [...]

Publisher

Journal

Year

Volume

7

Issue

3

Pages

337-342

Physical description

Dates

published
1 - 9 - 2009
online
21 - 6 - 2009

Contributors

author
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin University, 33169, Mersin, Turkey
author
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskisehir, Turkey
author
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, 33169, Mersin, Turkey
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, 33169, Mersin, Turkey
author
  • Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Mersin University, 33169, Mersin, Turkey

References

  • [1] M.A. Ghannoum, L.B. Rice, Clin. Microbiol. Rev. 12(4), 501 (1999)
  • [2] R.C. Boruah, E.B. Skibo, J. Med. Chem. 37, 1625 (1994) http://dx.doi.org/10.1021/jm00037a013[Crossref]
  • [3] The Merck Index, An Encyclopedia of Chemical Drugs and Biologicals, 12th edition (Merck and Co., Whitehouse Station NJ, 1996)
  • [4] M.R. Sahaaban, T.M.A. Eldebss, A.F. Darweesh, A.M. Farag, J. Heterocycl. Chem. 45, 1739 (2008) http://dx.doi.org/10.1002/jhet.5570450627[Crossref]
  • [5] A. Dandia, R. Singh, A.K. Jain, D. Singh, Synth. Commun. 38(20), 3543 (2008) http://dx.doi.org/10.1080/00397910802164732[Crossref]
  • [6] M.M. Heravi, L. Ranjbar, F. Derikvand, B. Alimadadi, H.A. Oskooie, F.F. Bamoharram, Molecular Diversity 12(3–4), 181 (2008) http://dx.doi.org/10.1007/s11030-008-9086-8[Crossref]
  • [7] E.I. Maiboroda, V.N. Britsun, Russ. J. Org. Chem. 44(8), 1200 (2008) http://dx.doi.org/10.1134/S1070428008080162[Crossref]
  • [8] H. Wahe, P.F. Asobo, R.A. Cherkasov, Z.T. Fomum, D. Doepp, Arkivoc 8, 1, 130 (2004)
  • [9] W. Nawrocka, M. Zimecki, Part 4 Arch. Pharm. Pharm. Med. Chem. 70, 193 (1996)
  • [10] K. Terashima, O. Muraoka, M. Ono, Chem. Pharm. Bull. 43(11), 1985 (1995) [Crossref]
  • [11] G. Trapani, M. Franco, A. Latrofa, G. Genchi, V. Lacobazzi, C.A. Ghiani, E. Maciocco, G. Liso, Eur. J. Med. Chem. 32, 83 (1997) http://dx.doi.org/10.1016/S0223-5234(97)84364-4[Crossref]
  • [12] Da A. Settimo, G. Primofiore, Da F. Settimo, A.M. Marini, S. Taliani, S. Salerno, Via L. Dalla, J. Heterocycl. Chem. 40, 1091 (2003) http://dx.doi.org/10.1002/jhet.5570400620[Crossref]
  • [13] S.M. Sondhi, R.P. Verma, V.K. Sharma, M.N. Singhal, J.L. Kraus, M. Camplo, J.-C. Chermann, Phosphorus Sulfur Silicon Relat. Elem. 122(1), 215 (1997) http://dx.doi.org/10.1080/10426509708043511[Crossref]
  • [14] T. Chiba, S. Shigeta, Y. Numazaki, Biol. Pharm. Bull. 18(8), 1081 (1995) [Crossref]
  • [15] C. Davidson, T.H. Lee, E.H. Ellinwood, Eur. J. Pharmacol. 499, 355 (2004) http://dx.doi.org/10.1016/j.ejphar.2004.08.006[Crossref]
  • [16] S. Lazareno, A. Popham, J.M. Birdsall, Mol. Pharmacol. 62, 1492 (2002) http://dx.doi.org/10.1124/mol.62.6.1492[Crossref]
  • [17] S.M. Sondhi, S. Rajvanshi, M. Johar, N. Bharti, A. Azam, A.K. Sing, Eur. J. Med. Chem. 37, 835 (2002) http://dx.doi.org/10.1016/S0223-5234(02)01403-4[Crossref]
  • [18] M. Larhed, A. Hallberg, Drug Discovery Today 6(8), 406 (2001) http://dx.doi.org/10.1016/S1359-6446(01)01735-4[Crossref]
  • [19] H.E. Blackwell, Org. Biomol. Chem. 1, 1251 (2003) http://dx.doi.org/10.1039/b301432k[Crossref]
  • [20] B. Wathey, J. Tierney, P. Lidström, J. Westman, Drug Discovery Today 7(6), 373 (2002) http://dx.doi.org/10.1016/S1359-6446(02)02178-5[Crossref]
  • [21] R.A. Abramovitch, Q. Shi, D. Bogdal, Synth. Commun. 25(1), 1 (1995) http://dx.doi.org/10.1080/00397919508010781[Crossref]
  • [22] D. Bradley, Modern Drug Discovery 4(8), 32 (2001)
  • [23] A. Meriç, Z. Incesu, A. Karayel, S. Özbey, Rec. Chim. (Bucureşti) 57(11), 1090 (2006)
  • [24] A. De Cat, A. Van Dormael, Bull. Soc. Chim. Belg. 59, 573 (1950) [Crossref]
  • [25] H. Wahe, P.F. Asobo, R.A. Cherkasov, A.E. Nkengfack, G.N. Folefoc, Z.T. Fomum, D. Doepp, Arkivoc XIV, 170 (2003)
  • [26] E.I. Al-Afaleq, J. Chem. Res. Synop. 30, 1985 (2000)
  • [27] K.M. Al-Zaydi, M.A. Al-Shiekli, E.A.A. Hafez, J. Chem. Res. Synop. 1, 13 (2000) http://dx.doi.org/10.3184/030823400103165716[Crossref]
  • [28] K.M. Dawood, A.M. Farag, Z.E. Kandeel, J. Chem. Res. Synop. 2, 88 (1999) http://dx.doi.org/10.1039/a807428c[Crossref]
  • [29] D.A.E. Ella, E. Grossnitzer, W. Wendelin, J. Heterocycl. Chem. 33, 373 (1996) http://dx.doi.org/10.1002/jhet.5570330228[Crossref]
  • [30] J.P. Bouillon, Z. Janousek, H.G. Viehe, B. Tinant, J.P. Declercq, J. Chem. Soc. 1, 2907 (1995)

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-009-0023-1
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.