Wydzielanie serotoniny i melatoniny oraz mioelektryczna i motoryczna czynność żołądka u kobiet po menopauzie

• Authors: Waldemar Jałocha , Patrycja Wachowska-Kelly , Agnieszka Stępień , Paweł Wojtkiewicz , Ewa Walecka-Kapica , Jan Chojnacki , Grażyna Klupińska

Title variants

EN

Secretion of the serotonin and melatonin and myoelectrical and motor gastric activity in postmenopausal women

• Languages of publication: PL

Abstracts

PL

U kobiet po menopauzie występują różnorodne zaburzenia psychosomatyczne, w tym dotyczące nastroju i łaknienia. Przyczyną tego jest niedobór estrogenów, ale także innych hormonów i neurotransmiterów. Celem badania było określenie stężenia serotoniny i melatoniny oraz czynności mioelektrycznej i motorycznej żołądka u kobiet po menopauzie w odniesieniu do ich stanu odżywienia. Badania przeprowadzono w trzech 30-sto osobowych grupach kobiet: przed menopauzą (grupa I), po menopauzie z prawidłową masą ciała (grupa II), po menopauzie ze współistniejącą nadwagą (grupa III). W porównaniu z grupą I, w grupie II nie stwierdzono istotnych różnic, natomiast w grupie III niższe było stężenie serotoniny, odpowiednio 156,5±40,2 ng/mL i 83,4±32,5 ng/mL (p<0,01), a także niższy był odsetek prawidłowej czynności mioelektrycznej żołądka (normogastrii) – 82,9±5,6% i 66,9±8,2 (p<0,05) oraz krótszy był czas połowicznego opróżniania żołądka (43,6±14,7 min. i 27,4±12,2 min.; p<0,01. Ponadto stwierdzono odwrotną zależność między wskaźnikiem masy ciała a stężeniem serotoniny (r = -0,4744) i melatoniny (r = -0,7146). Wyniki badań wskazują na udział serotoniny i melatoniny w patogenezie zaburzeń odżywiania u kobiet po menopauzie.

EN

In postmenopausal women various psychosomatic disorders concerning mood and appetite occur. The reason is not only estrogen deficiency, but also other hormones and neurotransmitters. The aim of the study was to estimate serotonin and melatonin levels and myoelectrical activity and gastric motor in postmenopausal women in relation to their nutritional status. The study was conducted in three 30-person groups of women: premenopausal (group I), postmenopausal with a normal body mass (group II), postmenopausal overweight (group III). Compared with group I, in group II there were no significant differences, while in group III serotonin level was lower respectively 156.5±40.2 ng/ml and 83.4±32.5 ng/ml (p<0.01), as well as the percentage of normogastria – 82.9±5.6% and 66.9±8.2 (p<0.05) and gastric emptying half-time 43.6±14.7 min and 27.4±12.2 min (p<0.01). Moreover, a negative correlation between body mass index and serotonin (r = -0.4744) and melatonin (r = -0.7146) levels was observed. The study results indicate the involvement of serotonin and melatonin in the pathogenesis of eating disorders in postmenopausal women.

Keywords

EN

body mass index; electrogastrography; elektrogastrografia; gastric emptying; melatonin; melatonina; menopause; menopauza; opróżnianie żołądkowe; serotonin; serotonina; wskaźnik masy ciała

Discipline

• MEDICINE: MEDICINE

• Publisher: Łódzkie Towarzystwo Naukowe
• Journal: Folia Medica Lodziensia
• Year: 2014
• Volume: 41
• Issue: 2
• Pages: 155-167

Contributors

author

Waldemar Jałocha

• Zakład Żywienia Klinicznego i Diagnostyki Gastroenterologicznej, Uniwersytet Medyczny w Łodzi

author

Patrycja Wachowska-Kelly

• Klinika Gastroenterologii, Uniwersytet Medyczny w Łodzi

author

Agnieszka Stępień

• Zakład Żywienia Klinicznego i Diagnostyki Gastroenterologicznej, Uniwersytet Medyczny w Łodzi

author

Paweł Wojtkiewicz

• Oddział Gastroenterologii, Szpital Marynarki Wojennej w Gdańsku

author

Ewa Walecka-Kapica

• Zakład Żywienia Klinicznego i Diagnostyki Gastroenterologicznej, Uniwersytet Medyczny w Łodzi

author

Jan Chojnacki

• Klinika Gastroenterologii, Uniwersytet Medyczny w Łodzi

author

Grażyna Klupińska

• Zakład Żywienia Klinicznego i Diagnostyki Gastroenterologicznej, Uniwersytet Medyczny w Łodzi

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• Document Type: paper