Squamous cell oesophageal cancer in retinoblastoma survivor: does germinal RB1 mutation influence chemo- and radiosensitivity?

• Authors: Tomasz Dworzecki , Beata Smolska-Ciszewska , Rafał Suwiński
• Languages of publication: EN

Abstracts

EN

The case of complete response of squamous cell oesophageal cancer to radiochemotherapy in patient previously operated due to hereditary retinoblastoma is presented. Second cancers in retinoblastoma survivors are the main cause of death in that group of patients in developed countries. There is little data on the outcome of treatment in those patients but the few papers available suggest rather poor prognosis. However, it is not clear whether the biology of cancer determined by RB gene mutation is responsible for that. The data suggesting decreased radio- and chemoresistance in cancers with decreased RB gene expression is discussed in the present paper. The role of that gene in the response to cancer treatment was showed in lung, breast and bladder cancer. Moreover, laboratory studies seem to confirm clinical observations and show that RB gene inhibition leads to increased cytotoxic effect of cisplatin, etoposide and 5-fluorouracil. It seems that without the incorporation of gene expression profiling into clinical practice further improvement in cancer treatment will be difficult to achieve.

Keywords

EN

case report; chemoresistance; radiosensitivity; retinoblastoma; second malignancy; squamous cell esophageal cancer

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2014
• Volume: 4
• Issue: 2
• Pages: A72-75

Contributors

author

Tomasz Dworzecki

• 2nd Clinic of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland

author

Beata Smolska-Ciszewska

• 2nd Clinic of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland

author

Rafał Suwiński

• 2nd Clinic of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie Institute of Oncology, Gliwice, Poland

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• Document Type: report