MMP-2 and MMP-9 as prognostic factors in ischaemic stroke

• Authors: Justyna Zielińska-Turek , Grzegorz Turek , Dominika Jakubowicz-Lachowska , Sławomir Ławicki , Robert Pogorzelski , Monika Chorąży , Wiesław Drozdowski

Title variants

PL

MMP-2 i MMP-9 jako czynniki prognostyczne w udarze niedokrwiennym mózgu

• Languages of publication: EN

Abstracts

EN

Objectives: No widely available, adequately sensitive diagnostic test to establish prognosis in stroke patients has been developed thus far. The aim of this study was to analyse changes in plasma levels of MMP-9 and MMP-2 as potential prognostic factors in patients with ischaemic stroke. Methods: The study included 56 patients presenting with the signs of ischaemic stroke for less than 24 hours, and 60 healthy controls without a history of neurological and/or inflammatory disorders. Plasma concentrations of MMP-2 and MMP-9 were determined immunoenzymatically at admission (i.e. within 24 hours of the cerebrovascular episode) and on the 7th day of hospital stay. Results: Median concentrations of MMP-9 in stroke patients were significantly lower than in the controls, both at admission and on the 7th day of hospital stay. No significant changes in the concentration of MMP-2 in ischaemic stroke patients were observed during the course of hospital stay. No significant association was found between both MMP concentrations and neurological status of patients with cerebrovascular episodes. Conclusions: The lack of significant associations between plasma concentrations of MMP-2/MMP-9 and clinical status suggests that these metalloproteinases should not be used as prognostic factors in patients with ischaemic cerebral episodes.

PL

Jak dotąd nie został opracowany szeroko dostępny, wystarczająco czuły test diagnostyczny oceniający rokowanie u pacjentów po udarze niedokrwiennym mózgu. Celem niniejszego badania była analiza zmian stężenia MMP-9 i MMP-2 w osoczu jako potencjalnych czynników prognostycznych u chorych z udarem niedokrwiennym mózgu. Metody: Do badania włączono 56 pacjentów z objawami udaru niedokrwiennego utrzymującymi się nie dłużej niż 24 godziny oraz 60 osób zdrowych, bez historii incydentów neurologicznych i/lub zapalnych. Stężenia MMP-2 i  MMP-9 oznaczono immunoenzymatycznie przy przyjęciu (czyli w ciągu 24 godzin od epizodu mózgowego) oraz 7. dnia hospitalizacji. Wyniki: Mediana stężenia MMP-9 w udarze mózgu była znacznie niższa niż w grupie kontrolnej, zarówno przy przyjęciu, jak i 7. dnia pobytu w szpitalu. Nie zaobserwowano znamiennych statystycznie zmian stężenia MMP-2 u osób z udarem niedokrwiennym mózgu w trakcie pobytu w szpitalu. Nie stwierdzono również istotnego związku między stężeniami obu MMP i stanem neurologicznym pacjentów z epizodami mózgowo-naczyniowymi. Wnioski: Brak istotnych związków pomiędzy stężeniami MMP-2/MMP-9 i obrazem klinicznym sugeruje, że metaloproteinazy nie powinny być stosowane jako czynniki prognostyczne u pacjentów z epizodami udaru niedokrwiennego mózgu.

Keywords

EN

ischaemic stroke; metalloproteinase 2; metalloproteinase 9; stroke

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Aktualności Neurologiczne
• Year: 2016
• Volume: 16
• Issue: 3
• Pages: 125–130

Contributors

author

Justyna Zielińska-Turek

• Department of Neurology, Medical University of Bialystok, Bialystok, Poland

author

Grzegorz Turek

• Department of Neurosurgery, Medical University of Bialystok, Bialystok, Poland

author

Dominika Jakubowicz-Lachowska

• Department of Neurology, Medical University of Bialystok, Bialystok, Poland

author

Sławomir Ławicki

• Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland

author

Robert Pogorzelski

• Department of Neurology, Medical University of Bialystok, Bialystok, Poland

author

Monika Chorąży

• Department of Neurology, Medical University of Bialystok, Bialystok, Poland

author

Wiesław Drozdowski

• Department of Neurology, Medical University of Bialystok, Bialystok, Poland

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• Document Type: article