Evaluation of bone metabolism in obese men and women with metabolic syndrome

• Authors: Magdalena Titz-Bober , Michał Holecki , Anna Hawrot-Kawecka , Magdalena Olszanecka-Glinianowicz , Jerzy Chudek , Anna Popkiewicz , Jan Duława

Title variants

PL

Wpływ zespołu metabolicznego na metabolizm kości otyłych mężczyzn i kobiet

• Languages of publication: EN

Abstracts

EN

BACKGROUND: It was suggested that metabolic syndrome (MS) is an additional risk factor that increases the risk of osteoporotic fractures. The aim of this study was to evaluate the impact of metabolic syndrome on bone metabolism and the risk of osteoporotic fracture in obese men and women. MATERIALS AND METHODS: The study involved 40 obese men and 40 obese women, divided into 2 subgroups: patients without MS (20 men and 20 women); and patients with MS (20 men and 20 women). The serum levels of PTH, 25-OH-D3, CTX1, osteocalcin, FGF23, total Ca and P were determined. The total absolute fracture risk was estimated using the Fracture Risk Assessment Tool. The control group consisted of 15 normal body mass, healthy men and women similar in age. RESULTS: Obese women with MS have a higher risk of osteoporotic fractures (3.0 vs. 1.6%; p < 0.001) and serum levels of phosphorus (1.8 vs. 1.12 mmol/l; p < 0.001) but lower 25(OH)D3 (7.3 vs. 34.6 ng/ml; p < 0.01) than obese women without MS. There were no differences in the risk of osteoporotic fracture or other study parameters between obese men with and without MS. Women with MS had lower serum CTX1 levels (0.27 ng/ml vs. 0.41 ng/ml; p < 0.05) than men. CONCLUSIONS: Metabolic syndrome does not influence the selected parameters of bone metabolism in either men or women. However, women with metabolic syndrome have lower serum 25-OH-D3 levels. Women, but not men with metabolic syndrome have a higher 10-year absolute fracture risk than obese women with-out metabolic syndrome.

PL

WSTĘP: Wydaje się, że zespół metaboliczny (MS) jest dodatkowym czynnikiem zwiększającym ryzyko złamań osteoporotycznych. Celem tego badania była ocena wpływu zespołu metabolicznego na metabolizm kości i ryzyko złamań osteoporotycznych u otyłych mężczyzn i kobiet. MATERIAŁ I METODY: W badaniu wzięło udział 40 otyłych mężczyzn i 40 otyłych kobiet. Badanych podzielono na 2 grupy: pacjentów z otyłością bez MS (20 mężczyzn i 20 kobiet) i pacjentów z MS (20 mężczyzn i 20 kobiet). W grupach badanych oznaczono w surowicy stężenie parathormonu (PTH), 25-OH-D3, C-końcowego usieciowanego peptydu kolagenu typu 1 (CTX1), osteokalcyny, FGF23, wapnia (Ca) i fosforu (P). Ryzyko złamania osteoporotycznego oszacowano, stosując skalę FRAX (Fracture Risk Assessmen Tool). Grupę kontrolną stanowiło 15 zdrowych mężczyzn i kobiet w podobnym wieku. WYNIKI: Otyłe kobiety z MS charakteryzowały się większym ryzykiem złamań osteoporotycznych (3,0 vs 1,6%; p < 0,001), stężeniem w surowicy fosforu (1,8 vs 1,12 mmol/l; p < 0,001) oraz mniejszym stężeniem 25-OH-D3 (7,3 vs 34,6 ng/ml; p < 0,01) w porównaniu z kobietami bez MS. Nie stwierdzono istotnych różnic w ryzyku złamań osteoporotycznych i stężeniach ocenianych parametrów między mężczyznami z otyłością bez MS i z MS. Kobiety z MS miały niższe stężenie CTX-1 (0,27 ng/ml vs. 0,41 ng/ml; p) w porównaniu z mężczyznami. WNIOSKI: Zespół metaboliczny nie wpływa na wskaźniki metabolizmu kostnego u mężczyzn i kobiet. Kobiety z zespołem metabolicznym charakteryzują się jednak mniejszym stężeniem 25-OH-D3. Kobiety, ale nie mężczyźni, z zespołem metabolicznym, wykazują większe 10-letnie ryzyko złamania osteoporotycznego niż kobiety z otyłością bez zespołu metabolicznego.

Keywords

EN

bone metabolism; fracture risk; metabolic syndrome; metabolizm kości; obesity; otyłość; ryzyko złamań; zespół metaboliczny

Discipline

• MEDICAL_BIOLOGY: MEDICAL BIOLOGY

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2016
• Volume: 70
• Pages: 133–142

Contributors

author

Magdalena Titz-Bober

• Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, Poland

author

Michał Holecki

• Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, ul. Ziołowa 45/47, 40-635 Katowice, Poland, tel.: [phone]

author

Anna Hawrot-Kawecka

• Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, Poland

author

Magdalena Olszanecka-Glinianowicz

• Department of Health Promotion and Obesity Management, Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland

author

Jerzy Chudek

• Department of Pathophysiology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland

author

Anna Popkiewicz

• Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, Poland

author

Jan Duława

• Department of Internal Medicine, School of Health Science in Katowice, Medical University of Silesia in Katowice, Poland

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• Document Type: article