Prognostic relevance of hyponatremia after first-ever ischemic stroke

• Authors: Bartłomiej Kret , Anetta Lasek-Bal , Michał Holecki , Anna Hawrot-Kawecka , Krzysztof Wilczyński , Jan Duława

Title variants

PL

Znaczenie hiponatremii u chorych z pierwszym w życiu udarem niedokrwiennym mózgu

• Languages of publication: EN

Abstracts

EN

INTRODUCTION: Hyponatremia is examined as a prognostic factor after first-time ischemic cerebrovascular incident (CVA, ischemic stroke). MATERIALS AND METHODS: 677 patients were analyzed after first-time ischemic stroke and divided into two groups according to sodium concentration: ≤ 135 mmol/L and > 135 mmol/L. RESULTS: For patients with sodium levels ≤ 135 mmol/L, the median National Institutes of Health Stroke Scale (NIHSS) score was 5 points, the median Modified Rankin Scale (mRS) was 4 points, and the mortality within 1 month of ischemic stroke was 10.5%. Patients with sodium levels > 135 mmol/L: NIHSS 3 points, mRS 2 points and mortality 1 month after ischemic stroke 3.4%. Mortality within 1 month of ischemic stroke in hyponatremic patients: women 16.4%, men 3.5% (p = 0.0194). Greater disability was seen in eunatremic women as assessed by increased mRS scores (p = 0.005). CONCLUSIONS: Hyponatremia is associated with a worsened heath status in patients in the acute and sub-acute phase after first-time ischemic stroke and is associated with increased mortality within 1 month after the stroke. Women with hyponatremia were characterized by greater mortality within one month after their first-ever ischemic stroke. In women with normal serum sodium at the time of stroke, a higher degree of disability was observed as assessed by increased mRS scores compared to men.

PL

WSTĘP: Hiponatremię uważa się za czynnik ryzyka udaru mózgu. MATERIAŁ I METODY: Przeanalizowano 677 chorych z pierwszym w życiu udarem niedokrwiennym mózgu, których podzielono w zależności od stężenia sodu w surowicy na dwie podgrupy: ≤ 135 mmol/l i > 135 mmol/l. WYNIKI: U chorych ze stężeniem sodu ≤ 135 mmol/l mediana w skali NIHSS wyniosła 5 pkt, mediana oceny stopnia inwalidztwa według skali mRankin wynosiła 4 pkt, a śmiertelność w okresie jednego miesiąca od zachorowania wynosiła 10,5%, w grupie ze stężeniem sodu > 135 mmol/l stwierdzono odpowiednio: 3 pkt, 2 pkt, i 3,4%. U chorych z hiponatremią śmiertelność w ciągu miesiąca od zachorowania wynosiła u kobiet 16,4%, u mężczyzn 3,5% (p = 0,0194). U kobiet z prawidłową natremią obserwowano większy stopień inwalidztwa w skali mRankin (p = 0,005). WNIOSKI: Hiponatremia ma niekorzystny wpływ na stan pacjentów zarówno w ostrej, jak i podostrej fazie udaru oraz wiąże się ze zwiększoną śmiertelnością miesięczną od zachorowania. Kobiety z hiponatremią cechowała większa śmiertelność w ciągu jednego miesiąca po przebytym pierwszym w życiu udarze niedokrwiennym. U kobiet z prawidłowym stężeniem sodu w czasie pierwszego w życiu udaru niedokrwiennego stwierdzano wyższy stopień inwalidztwa ocenianego w skali mRankin w porównaniu z mężczyznami.

Keywords

EN

czynniki ryzyka; hiponatremia; hyponatremia; prognosis; risk factors; rokowanie; stroke; udar

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2016
• Volume: 70
• Pages: 127–132

Contributors

author

Bartłomiej Kret

• Department of Neurology, Medical University of Silesia in Katowice, Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland

author

Anetta Lasek-Bal

• Department of Neurology, Medical University of Silesia in Katowice, Hospital No. 7, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, Poland, Faculty of Physiotherapy – Institute of Rehabilitation Medicine, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland

author

Michał Holecki

• Department of Internal Medicine and Metabolic Disease, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, ul. Ziołowa 45-47, 40-635 Katowice, Poland, tel. [phone]

author

Anna Hawrot-Kawecka

• Department of Internal Medicine and Metabolic Disease, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland

author

Krzysztof Wilczyński

• Department of Geriatrics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland

author

Jan Duława

• Department of Internal Medicine and Metabolic Disease, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland

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• Document Type: article