The effect of alpha-tocopherol in the acute ethanol intake and its withdrawal on penicillin-induced epilepsy

• Authors: R. Kozan , M. Ayyildiz , M. Yildirim , E. Agar
• Languages of publication: EN

Abstracts

EN

The present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.), the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/ kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats.

Keywords

EN

ALPHA-TOCOPHEROL; EPILEPTIFORM ACTIVITY; ETHANOL; PENICILLIN

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2009
• Volume: 69
• Issue: 2
• Pages: 177-188

Contributors

author

R. Kozan

author

M. Ayyildiz

author

M. Yildirim

author

E. Agar

• Document Type: ARTICLE
• Publication order reference: Erdal Agar, Department of Physiology, Faculty of Medicine, University of Ondokuz Mayis, 55139 Samsun, Turkey