The influence of sorbitol on photooxidation-mediated crosslinking of porcine pericardial collagen

• Authors: G. Wisowski , K. Olczyk , E.M. Kozma , A. Jura-Poltorak , P. Olczyk , K. Kuznik-Trocha
• Languages of publication: PL

Abstracts

EN

Collagen is one of the most useful biomaterials. The medical application of collagen tissues requires specific fixation procedures. Dye-mediated photooxidation is a method of the new collagen crosslink formation. In this study, the influence of sorbitol on the extent of porcine pericardial collagen crosslinking was investigated. The collagen modification was estimated on the basis of pericardial susceptibility to pepsin digestion. The hydrolysate components were characterized electrophoretically. The significant collagen crosslinking was found in all photooxidized samples, in comparison with the untreated ones. However, the most enhanced collagen modification was observed for pericardium photooxidized with 0,5% and 0,9% sorbitol, as compared to the samples fixed without sorbitol.

Keywords

EN

COLLAGEN; PHOTOOXIDATION; SORBITOL

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2005
• Issue: 4
• Pages: 189-196

Contributors

author

G. Wisowski

author

K. Olczyk

author

E.M. Kozma

author

A. Jura-Poltorak

author

P. Olczyk

author

K. Kuznik-Trocha

• Document Type: ARTICLE
• Publication order reference: Grzegorz Wisowski, Katedra i Zaklad Chemii Klinicznej i Diagnostyki Laboratoryjnej, Slaska Akademia Medyczna, ul. Jagiellonska 4, 41-200 Sosnowiec, Poland