Influence of acetaldehyde on some serotonergic mechanism in rat blood platelets

• Authors: Dariusz Pawlak , Ewa Chabelska , Wlodzimierz Buczko
• Languages of publication: EN

Abstracts

EN

Acetaldehyde (ACT), both, ex vivo and in vitro did not change the ADP-induced rat platelet aggregation and the potentiating action of serotonin. The whole blood serotonin content was decreased only when ACT was used in doses of 20 and 30 mg/kg, iv and the platelet serotonin content remained unchanged. Ex vivo, ACT had no influence on the labeled serotinin uptake, whereas in experiments in vitro it inhibited the amine uptake and augmented the serotonin release from blood platelets in a dose dependent manner. The results indicate that all the changes in the platelet serotonergic mechanisms appear only after high concentrations of ACT. They may be of significant importance in the circulatory system or hemostasis only during disulfiram or calcium carbamide therapy.

Keywords

EN

ACETALDEHYDE; PLATELET AGGREGATION; SEROTONIN

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 1
• Pages: 59-66

Contributors

author

Dariusz Pawlak

author

Ewa Chabelska

author

Wlodzimierz Buczko

• Document Type: article