The role HTLV-I in the T lymphocytes transformation

• Authors: M. Papiez
• Languages of publication: PL

Abstracts

EN

HTLV-I virus is as etiological agent of adult T-cell leukemia (ATL).The virus encodes Tax regulatory protein, which induces malignant transformation of the T lymphocytes.Tax increases the expression of cell protooncogenes as well as lymphokines, among others IL-2 and its receptor.This protein induces autocrine proliferation of T lymphocytes, which is probably the main cause of their transformatn.Tax represses the human beta-polymerase gene enzyme involved in host cell DNA repair, and then inversible damage is effected in the T lymphocyte genome.Moreover, this regulatory protein cooperates with Rex phosphoprotein, stabilizing cell mRNA, which originate as the result of Tax protein activity.The regulatory proteins of HTLV-I virus influence the transcription of some genes their products and this way induce malignant transformation.

Keywords

EN

ACTIVATOR/DNA-BINDNG PROTEIN; HUMAN T-CELL; LEUKEMIA VIRUS; ONCOGENE/TRANSCRIPTIONAL; REX FUNCTION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1995
• Volume: 49
• Issue: 5
• Pages: 585-597

Contributors

author

M. Papiez

• Document Type: article
• Publication order reference: M.Papiez