Effective tumor immunotherapy: start the engine, release the brakes, step on the gas, ...and get ready to face autoimmunity

• Authors: I. Tirapu , G. Mazzolini , M. Rodriguez-Calvillo , A. Arina , B. Palencia , I. Gabari , I. Melero
• Languages of publication: EN

Abstracts

EN

Cellular immune responses can destroy cancer cells, achieving the cure of experimental malignancies. An expanding wealth of knowledge on the molecular basis of how to prime and amplify a T cell response has fueled a number of strategies successful at treating established tumors (rather than merely preventing tumor grafting). The most efficacious approaches operate at different stages, including: 1) priming the immune response using tumor antigen-expressing dendritic cells or tumor cells transfected with genes that render them immunogenic, 2) sustaining and amplifying immunity using agonistic monoclonal antibodies against costimulatory molecules or immune-potentiating cytokines, and 3) eliminating mechanisms that self-regulate the strength of the immune response, such as inhibitory receptors or regulatory T cells. A rational combination of such approaches holds great hope for cumulative and synergistic effects, but there is also evidence that they can open the flood-gates for unwanted inflammatory reactions. The next decade can be envisioned as the time when the first reproducibly efficacious combination regimes for cancer immunotherapy will become available and widely used in the clinic, as clinicians learn the best strategies and try to harness their potentially damaging effects.

Keywords

EN

COSTIMULATION; CYTOKINE; DENDRITIC CELL; IMMUNOTHERAPY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 1
• Pages: 13-18

Contributors

author

I. Tirapu

author

G. Mazzolini

author

M. Rodriguez-Calvillo

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A. Arina

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B. Palencia

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I. Gabari

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I. Melero

• Document Type: REVIEW
• Publication order reference: I.Tirapu, Gene Therapy Division, Facultad de Medicina and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain