Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

• Authors: Katarzyna Rozwadowska , Ludmiła Daniłowicz-Szymanowicz , Marcin Fijałkowski , Katarzyna Sikorska , Wiktor Szymanowicz , Ewa K. Lewicka , Grzegorz Raczak
• Languages of publication: EN

Abstracts

EN

Background Hereditary haemochromatosis (HH) is an inherited disease in which gene mutation leads to excessive iron absorption and accumulation in different organs, including the heart, which causes damage. Whether the age of patients with HH at the moment of their first diagnosis has an additional effect on the standard echocardiographic parameters was the aim of the study. Material and methods We prospectively enrolled 20 HH patients, and 20 healthy age- and sex-matched volunteers. Analysis of standard echocardiographic parameters was performed and compared in subgroups of ≥50 and <50 years old (yo). Results Comparing HH patients with healthy volunteers in ≥50 yo subgroup, significant differences were found in parameters regarding diastolic function (IVS thickness, LVM index, Em, E/Em, PV S/D, LAA index and LAV index). In the <50 yo subgroup we did not find the abovementioned differences, however LVEF appeared to be lower in the HH patients. Conclusions Despite the lack of clinical symptoms of cardiovascular disease and the lack of deviations in the standard echocardiographic examination, there were a number of differences regarding LV diastolic function parameters in HH patients ≥50 yo, whereas differences regarding LV systolic function were more prominent in HH patients <50 yo when compared with healthy subjects.

Keywords

EN

age; echocardiography; hereditary hemochromatosis

• Journal: European Journal of Translational and Clinical Medicine
• Year: 2018
• Volume: 1
• Issue: 1
• Pages: 20-25

Dates

published

2018-09-28

received

2018-07-02

accepted

2018-09-18

Contributors

author

Katarzyna Rozwadowska

author

Ludmiła Daniłowicz-Szymanowicz

author

Marcin Fijałkowski

author

Katarzyna Sikorska

author

Wiktor Szymanowicz

author

Ewa K. Lewicka

author

Grzegorz Raczak

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Identifiers

DOI

10.31373/ejtcm/95222