ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF NEW ANALOGUES OF HC-030031: A TRPA1 CHANNEL ANTAGONIST

• Authors: Adrian Bryła , Marietta Ślusarczyk , Małgorzata Zygmunt , Grażyna Chłoń-Rzepa , Grzegorz Kazek
• Languages of publication: EN

Abstracts

EN

One of our study direction is research in the group of compounds affecting the TRPA1 ion channel which can perform an important function in pain (including neuropathic pain) and inflammation for example in asthma and other chronic respiratory diseases. The aim of this study was to evaluate the analgesic and anti-inflammatory activity of two analogues of HC-030031 analogues belonging to nitrogen derivatives of heterocyclic system: xanthine (cmpd 1) and benzimidazole (cmpd 2) with hydrazide and amide moieties respectively In this paper, for two derivatives (cmpd 1 and cmpd 2) potential analgesic and anti-inflammatory/anti-edematous activities were evaluated in animal models of pain in mice (writhing response test, formalin test) and inflammation in rats (carrageenan-induced paw edema test). Both the tested compounds 1 and 2 showed a significant analgesic and anti-inflammatory activity.

Keywords

EN

inflammation; pain; TRPA1 channels; HC-030031 analogues

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2020
• Volume: 77
• Issue: 1
• Pages: 113-119

Dates

published

2020-02-29

Contributors

author

Adrian Bryła

author

Marietta Ślusarczyk

author

Małgorzata Zygmunt

author

Grażyna Chłoń-Rzepa

author

Grzegorz Kazek

Identifiers

DOI

10.32383/appdr/117836