Dioscin improves survival in murine endotoxemia induced by Lipopolysaccharide

• Authors: Han Bing , Lu Jing , Liu Meitong , Feng Zhe , Guan shuang
• Languages of publication: EN

Abstracts

EN

Dioscin is a natural steroidal saponin mainly exacted from Dioscoreae Rhizoma, which usually used as traditional medicine in east asia area. Dioscin has various pharmacological actions. However, little is known concerning the role on Lipopolysaccharide (LPS)-induced endotoxemia. The aim of the present study was to investigate the effects and possible mechanisms of dioscin against LPS-induced endotoxemia in mice. The data showed dioscin significantly increased mouse survival when mice were treated with dioscin prior to or after LPS challenge and significantly attenuated TNF-α, IL-1β and IL-6 production in serum. Further studies revealed that dioscin could downregulate LPS-induced nuclear transcription factor - қB (NF-қB) signal transduction pathways. These observations indicated that dioscin modulated early cytokine responses by blocking NF-қB activation, and thus, increased mouse survival in murine endotoxemia induced by LPS.

Keywords

EN

cytokines; survival; Endotoxemia; Dioscin; NF- қB

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 6
• Pages: 1347-1352

Dates

published

2018-12-31

Contributors

author

Han Bing

author

Lu Jing

author

Liu Meitong

author

Feng Zhe

author

Guan shuang

Identifiers

DOI

10.32383/appdr/89676