Synthesis and anticancer activity evaluation of novel derivatives of 7-amino-4-methylquinolin-2(1H)-one

• Authors: Krzysztof P. Kubica , Przemyslaw P. Taciak , Agnieszka Czajkowska , Alicja Sztokfisz-Ignasiak , Rafal Wyrebiak , Izabela Mlynarczuk-Bialy , Jacek Malejczyk , Aleksander P. Mazurek
• Languages of publication: EN

Abstracts

EN

In this study we designed and synthesized sixteen new derivatives of 7-amino-4-methylquinolin-2(1H)-one with potential anticancer activity. The structures of synthesized compounds were confirmed by 1H and 13C NMR. The activity of novel substances was evaluated by cell viability assay and wound healing assay. In vitro tests for series of sixteen novel compounds were performed. The results showed that examined compounds are selective for cancer cells, but their activity for various types of cancer is different. Three of new compounds presented ability to inhibit cells migration. The novel compounds constitute a good starting point for further studies and optimization of structure for new therapeutically effective anti-cancerous drugs. Seven compounds, which showed the highest rate of cell inhibition, were selected for further studies.

Keywords

EN

anticancer activity; cytotoxicity assay; cell migration assay; quinolin-2(1H)-one

• Journal: Acta Poloniae Pharmaceutica - Drug Research
• Year: 2018
• Volume: 75
• Issue: 4
• Pages: 903-910

Dates

published

2018-08-31

Contributors

author

Krzysztof P. Kubica

author

Przemyslaw P. Taciak

author

Agnieszka Czajkowska

author

Alicja Sztokfisz-Ignasiak

author

Rafal Wyrebiak

author

Izabela Mlynarczuk-Bialy

author

Jacek Malejczyk

author

Aleksander P. Mazurek

Identifiers

DOI

10.32383/appdr/79279