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Journal

2017 | 66 | 4 | 609-621

Article title

Receptory rozpoznające wirusowe kwasy nukleinowe w odpowiedzi przeciwwirusowej ryb

Content

Title variants

EN
Receptors recognizing viral nucleic acids during immune response of fish

Languages of publication

PL EN

Abstracts

PL
Kluczowym etapem nieswoistej reakcji odpornościowej organizmu na zakażenie wirusowe jest szybkie wykrycie obecności wirusów w komórce i aktywacja syntezy interferonów (IFN) typu I. Wirusowe kwasy nukleinowe (DNA i RNA) są głównymi strukturami pochodzenia wirusowego rozpoznawanymi przez receptory wrodzonego układu odpornościowego. Wśród receptorów rozpoznających te struktury bardzo istotną rolę odgrywają receptory Toll-podobne (TLR) i RIG-I-podobne (RLR). Wiele z tych receptorów opisanych u ssaków występuje także u ryb, chociaż z drugiej strony ryby posiadają także receptory, które nie zostały zidentyfikowane u ssaków. Ryby, które są pierwszymi kręgowcami z pełni rozwiniętym układem odpornościowym wrodzonym i nabytym, stanowią doskonały model do badania ewolucji mechanizmów odporności u kręgowców. W pracy przedstawiono receptory rozpoznające wirusowe kwasy nukleinowe opisane u ryb oraz główne białka adaptorowe biorące udział w przekazywaniu sygnału wewnątrzkomórkowego w celu aktywacji syntezy IFN typu I i cytokin prozapalnych.
EN
Recognition of the non-self signature of invading viruses is a crucial step for the initiation of the anti-viral innate immune defense mechanisms including interferon (IFN) type I production. Viral nucleic acids occur the main virus-derived structures to be recognized by the receptors of the innate immune system. There are a number of receptors that recognize viral nucleic acids among which the most important are Toll-like receptors (TLR) and RIG-I-like receptors (RLR). Many of those receptors described in mammals have been also found in fish, although fish possess some specific receptors which have not been characterized in mammals. Teleost fish represent a relevant model for the study of the core immune mechanisms activated by viral infections. In this work we review the current knowledge about the fish receptors for viral nucleic acids and the main adaptor proteins involved in signaling pathways for the activation IFN type I and pro-inflammatory cytokine synthesis.

Journal

Year

Volume

66

Issue

4

Pages

609-621

Physical description

Dates

published
2017

Contributors

  • Zakład Immunologii Ewolucyjnej, Instytut Zoologii i Badań Biomedycznych, Uniwersytet Jagielloński, Gronostajowa 9, 30-387 Kraków, Polska
  • Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland
  • Zakład Immunologii Ewolucyjnej, Instytut Zoologii i Badań Biomedycznych, Uniwersytet Jagielloński, Gronostajowa 9, 30-387 Kraków, Polska
  • Department of Evolutionary Immunology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland

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