Mechanochemical Synthesis and Characterization of II-VI Nanocrystals: Challenge for Cytotoxicity Issues

• Authors: P. Baláž , R. Jardin , E. Dutková , M. Sayagués , M. Baláž , G. Mojžišová , J. Mojžiš , E. Turianicová , M. Fabián
• Languages of publication: EN

Abstracts

EN

CdSe@ZnS nanocrystals have been prepared by a two-step solid state mechanochemical synthesis. CdSe prepared from elements in the first step is mixed with ZnS synthesized from zinc acetate and sodium sulfide in the second step. The crystallite size of the new type CdSe@ZnS nanocrystals determined by X-ray diffraction Rietveld refined method was 35 nm and 10 nm for CdSe and ZnS, respectively. Energy dispersive/transmission electron microscopy/energy dispersive spectroscopy methods show good crystallinity of the nanoparticles and scanning electron microscopy elemental mapping illustrate consistent distribution of Cd, Se, Zn and S elements in the bulk of samples. UV-VIS spectra show an onset at 320 nm with calculated bandgap 3.85 eV. This absorption arises from the vibration modes of Zn-S bonds. The nanocrystals show the blue shift from the bandgap of bulk ZnS (3.66 eV). The synthesized CdSe@ZnS nanocrystals have been tested for dissolution, cytotoxicity and L-cysteine conjugation. The dissolution of Cd was less than 0.05 μg mL^{-1} (in comparison with 0.8 μg mL^{-1} which was evidenced for CdSe alone). The very low cytotoxic activity for selected cancer cell lines has been evidenced. CdSe@ZnS nanocrystals coated with L-cysteine are water-soluble and have a great potential in biomedical engineering as fluorescent labels.

Keywords

EN

81.05.Dz; 81.07.Bc; 81.20.Ka; 81.20.Wk

Discipline

• 81.20.Wk: Machining, milling
• 81.05.Dz: II-VI semiconductors
• 81.07.Bc: Nanocrystalline materials
• 81.20.Ka: Chemical synthesis; combustion synthesis(for electrochemical synthesis, see 82.45.Aa)

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2012
• Volume: 122
• Issue: 1
• Pages: 224-229

Dates

published

2012-07

received

2011-09-22

(unknown)

2012-02-15

Contributors

author

P. Baláž

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04353 Košice, Slovakia

author

R. Jardin

• Bruker AXS GmbH, Karlsruhe, Germany

author

E. Dutková

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04353 Košice, Slovakia

author

M. Sayagués

• Institute of Materials Science of Seville, Sevilla, Spain

author

M. Baláž

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04353 Košice, Slovakia

author

G. Mojžišová

• P.J. Šafárik University, Faculty of Medicine, Košice, Slovakia

author

J. Mojžiš

• P.J. Šafárik University, Faculty of Medicine, Košice, Slovakia

author

E. Turianicová

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04353 Košice, Slovakia

author

M. Fabián

• Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 45, 04353 Košice, Slovakia

References

• 1. Semiconductor Nanocrystal Quantum Dots, Ed. A.L. Rogach, Springer, Wien 2008
• 2. W.J. Parak, D. Gerion, T. Pellegrino, D. Zanchet, Ch. Michael, S.C. Williams, R. Boudreau, M.A. Le Gros, C.A. Larabell, A.P. Alivisatos, Nanotechnology 14, R15 (2003)
• 3. W.C. Chan, S. Nie, Science 281, 2016 (1998)
• 4. A.M. Derfus, W.C.W. Chan, S.N. Bhatia, Nano Lett. 4, 11 (2004)
• 5. W.H. Liu, H.S. Choi, J.P. Zimmer, E. Tanaka, J.V. Frangioni, M. Bawendi, J. Am. Chem. Soc. 129, 14530 (2007)
• 6. J.E. Bowen-Katari, V.L. Colvin, A.P. Alivisatos, J. Phys. Chem. 98, 4109 (1994)
• 7. Z.A. Peng, X. Peng, J. Am. Chem. Soc. 124, 3343 (2002)
• 8. R. Hardman, Environ. Health Persp. 114, 165 (2006)
• 9. M.A. Hines, P. Guyot-Sionnest, J. Phys. Chem. 100, 468 (1996)
• 10. I.L. Medintz, H.T. Uyeda, E.R. Goldman, H. Mattoussi, Nat. Mater. 4, 435 (2005)
• 11. H.Y. Xie, J.G. Liang, Y. Liu, Z.L. Zhang, D.W. Pang, Z.K. He, Z.X. Lu, W.H. Huang, J. Nanosci. Nanotechnol. 5, 880 (2005)
• 12. H. Ehrlich, T. Scherba, M. Zhilenko, G. Lisichkin, Mater. Lett. 65, 107 (2011)
• 13. G.L. Tan, J.H. Du, Q.J. Zhang, J. Alloy. Comp. 468, 421 (2009)
• 14. E. Dutková, P. Baláž, P. Pourghahramani, S. Velumani, J.A. Ascencio, N.G. Kostova, J. Nanosci. Nanotechnol. 9, 6600 (2009)
• 15. A. Chatterjee, A. Priryam, S.K. Das, A. Saha, J. Colloid Interf. Sci. 294, 334 (2006)
• 16. P.K. Sapathy, G.C. Dash, P. Mohanty, Indian J. Chem. 47A, 1199 (2008)
• 17. H. Bao, X. Cui, C.M. Li, J. Zang, Nanotechnology 18, 455701 (2007)
• 18. T.J. Mosmann, J. Immunol. Meth. 65, 55 (1983)

Identifiers

DOI

10.12693/APhysPolA.122.224