Contributions of the Hfq protein to translation regulation by small noncoding RNAs binding to the mRNA coding sequence

• Authors: Zuzanna Wroblewska , Mikolaj Olejniczak
• Languages of publication: EN

Abstracts

EN

The bacterial Sm-like protein Hfq affects the regulation of translation by small noncoding RNAs (sRNAs). In this way, Hfq participates in the cell adaptation to environmental stress, regulation of cellular metabolism, and bacterial virulence. The majority of known sRNAs bind complementary sequences in the 5'-untranslated mRNA regions. However, recent studies have shown that sRNAs can also target the mRNA coding sequence, even far downstream of the AUG start codon. In this review, we discuss how Hfq contributes to the translation regulation by those sRNAs which bind to the mRNA coding sequence.

Keywords

EN

Hfq; sRNA; mRNA; coding sequence; RNase E; ribosome

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 4
• Pages: 701-707

Dates

published

2016

received

2016-06-06

revised

2016-10-11

accepted

2016-10-13

(unknown)

2016-11-23

Contributors

author

Zuzanna Wroblewska

• Department of Biochemistry, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznań, Poznań, Poland

author

Mikolaj Olejniczak

• Department of Biochemistry, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University in Poznań, Poznań, Poland

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Identifiers

DOI

10.18388/abp.2016_1362