Retroposition as a source of antisense long non-coding RNAs with possible regulatory functions

• Authors: Oleksii Bryzghalov , Michał Szcześniak , Izabela Makałowska
• Languages of publication: EN

Abstracts

EN

Long non-coding RNAs (lncRNAs) are a class of intensely studied, yet enigmatic molecules that make up a substantial portion of the human transcriptome. In this work, we link the origins and functions of some lncRNAs to retroposition, a process resulting in the creation of intronless copies (retrocopies) of the so-called parental genes. We found 35 human retrocopies transcribed in antisense and giving rise to 58 lncRNA transcripts. These lncRNAs share sequence similarity with the corresponding parental genes but in the sense/antisense orientation, meaning they have the potential to interact with each other and to form RNA:RNA duplexes. We took a closer look at these duplexes and found that 10 of the lncRNAs might regulate parental gene expression and processing at the pre-mRNA and mRNA levels. Further analysis of the co-expression and expression correlation provided support for the existence of functional coupling between lncRNAs and their mate parental gene transcripts.

Keywords

EN

lncRNAs; long non-coding RNAs; retroposition; retrocopies; antisense transcription; RNA:RNA duplexes

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 4
• Pages: 825-833

Dates

published

2016

received

2016-06-04

revised

2016-06-30

accepted

2016-07-19

(unknown)

2016-11-02

Contributors

author

Oleksii Bryzghalov

• Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznań, Poland

author

Michał Szcześniak

• Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznań, Poland

author

Izabela Makałowska

• Department of Integrative Genomics, Institute of Antropology, Adam Mickiewicz University in Poznan, Poznań, Poland

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Identifiers

DOI

10.18388/abp.2016_1354