Structure and function of RNA elements present in enteroviral genomes

• Authors: Mariola Dutkiewicz , Aleksandra Stachowiak , Agata Swiatkowska , Jerzy Ciesiołka
• Languages of publication: EN

Abstracts

EN

Enteroviruses are small RNA(+) viruses that encode one open reading frame flanked by two extensive noncoding regions carrying structural RNA regulatory elements that control replication and translation processes. For a long time the central, coding region was thought to remain single-stranded and its only function was supposed to be as the template for polyprotein synthesis. It turned out, however, that the protein coding region also encodes important RNA structures crucial for the viral life cycle and virus persistence in the host cells. This review considers the RNA structures in enteroviral genomes identified and characterized to date.

Keywords

EN

Enterovirus; poliovirus; coxsackievirus B3; RNA structure; structural RNA element; cis-acting element

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2016
• Volume: 63
• Issue: 4
• Pages: 623-630

Dates

published

2016

received

2016-05-31

revised

2016-06-28

accepted

2016-08-12

(unknown)

2016-11-10

Contributors

author

Mariola Dutkiewicz

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

author

Aleksandra Stachowiak

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

author

Agata Swiatkowska

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

author

Jerzy Ciesiołka

• Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland

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Identifiers

DOI

10.18388/abp.2016_1337