Protective effects of quercetin on cadmium fluoride induced oxidative stress at different intervals of time in mouse liver

• Authors: Seema Zargar , Nikhat Siddiqi , Sooad Al Daihan , Tanveer Wani
• Languages of publication: EN

Abstracts

EN

Quercetin, a member of the flavonoid family is a major antioxidant acquired in humans by food consumption, while Cadmium fluoride (CdF2) is one of the naturally occurring chemicals having adverse effects. The protective effect of quercetin on time dependent oxidative damage induced in mice liver by CdF2 was studied in the following groups of mice consisting of six mice each: (i) control group; (ii) mice treated with single i.p injection of 2 mg/kg bw CdF2 for 24 h; (iii) mice treated with single i.p injection of 2 mg/kg bw CdF2 for 48 h; (iv) mice treated with single i.p injection of quercetin (100 mg/kg bw); (v) mice treated with i.p injection of 100 mg/kg bw of quercetin followed by i.p injection of CdF2 (2 mg/kg bw) for 24 h; and (vi) mice treated with i.p injection of 100mg/kg bw of quercetin followed by CdF2 (2 mg/kg bw) for 48 h. Administration of quercetin two hours before CdF2 significantly reduced the biochemical alterations in reduced glutathione, ascorbic acid, lipid peroxidation, super oxide dismutase, catalase and total protein (p<0.05). Histopathology also showed the protective effect of quercetin. The livers treated with CdF2 were atrophic, markedly nodular, inflamed and necrotic. However, this effect was reduced to a minimum in the mice pre-treated for two hours with quercetin.

Keywords

EN

cadmium fluoride; quercetin; oxidative stress; flavonoids; histology; adverse effect

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2015
• Volume: 62
• Issue: 2
• Pages: 207-213

Dates

published

2015

received

2014-09-23

revised

2015-03-01

accepted

2015-03-03

(unknown)

2015-04-09

Contributors

author

Seema Zargar

• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

author

Nikhat Siddiqi

• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

author

Sooad Al Daihan

• Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia

author

Tanveer Wani

• Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia

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Identifiers

DOI

10.18388/abp.2014_900