Evaluation of clinical usefulness of serum neopterin determination in children with bacterial infections

• Authors: Katarzyna Plata-Nazar , Grażyna Luczak , Anna Liberek , Julita Dudzinska-Gehrmann , Katarzyna Sznurkowska , Piotr Landowski , Barbara Kaminska
• Languages of publication: EN

Abstracts

EN

Neopterin (NPT) (6-D-erythro-trihydroxypropyl pteridin) is one of the indicators of the immune system activity. Elevated neopterin concentration occurs in diseases mostly involving stimulation of cellular immunity. The determination of neopterin concentration, usually in blood serum and urine but also in many other bodily fluids, has already been applied in many areas of medicine, such as transfusiology, transplantology, oncology, infectious diseases and autoimmunological diseases. Objective. The aim of this work is to evaluate clinical usefulness of serum neopterin determination in children with urinary tract infections of confirmed bacterial etiology. Material. The study involved 56 children with bacterial urinary tract infections - patients of the Clinic of Paediatrics, Paediatric Gastroenterology, Hepatology & Paediatric Nutrition of Medical University of Gdańsk in the years 2012-2013. The control group included 105 healthy children. Results. The values of NPT concentration in blood serum obtained in the group of children with urinary tract infections did not significantly differ from the values obtained in the control group. Conclusions. The determination of neopterin concentration in children with bacterial urinary tract infections is not a clinically useful parameter.

Keywords

EN

neopterin; children; urinary tract infections

• Publisher: Polish Biochemical Society
• Journal: Acta Biochimica Polonica
• Year: 2015
• Volume: 62
• Issue: 1
• Pages: 133-137

Dates

published

2015

received

2014-09-12

revised

2014-11-17

accepted

2014-11-20

online

2015-02-06

Contributors

author

Katarzyna Plata-Nazar

• Department of Paediatrics, Paediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdańsk, Poland

author

Grażyna Luczak

• Department of Paediatrics, Paediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdańsk, Poland

author

Anna Liberek

• Faculty of Health Sciences with Subfaculty of Nursing, Medical University, of Gdansk, Gdańsk, Poland

author

Julita Dudzinska-Gehrmann

• Department of Cardiology ZOZ MSW in Gdansk, Gdańsk, Poland

author

Katarzyna Sznurkowska

• Department of Paediatrics, Paediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdańsk, Poland

author

Piotr Landowski

• Department of Paediatrics, Paediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdańsk, Poland

author

Barbara Kaminska

• Department of Paediatrics, Paediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdańsk, Poland

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